1. Signaling Pathways
  2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. ADC Linker Inhibitors

ADC Linker Inhibitors

Cleavable Linker

Non-cleavable Linker

Acid Cleavable Linker

Disulfide Cleavable Linker

Protease Cleavable Linker

Glycosidase Cleavable Linker

Phosphatase Cleavable Linker

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ADC Linker
Product Name Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker Purity
DSS Crosslinker  
Non-cleavable Linker
          ≥98.0%
Mc-Val-Cit-PABC-PNP
Cleavable Linker
     
Protease Cleavable Linker
    98.89%
DBCO-NHS ester
Cleavable Linker
            99.53%
MC-Val-Cit-PAB
Cleavable Linker
     
Protease Cleavable Linker
    99.38%
Sulfo-SMCC sodium  
Non-cleavable Linker
         
DSG Crosslinker
Cleavable Linker
            98.13%
DSP Crosslinker
Cleavable Linker
   
Disulfide Cleavable Linker
      98.73%
Fmoc-3VVD-OH
Cleavable Linker
            99.99%
Val-cit-PAB-OH
Cleavable Linker
     
Protease Cleavable Linker
    99.62%
Maleimide-DOTA  
Non-cleavable Linker
          99.17%
SPDP
Cleavable Linker
   
Disulfide Cleavable Linker
      ≥98.0%
MAC glucuronide linker-2
Cleavable Linker
       
Glycosidase Cleavable Linker
  99.38%
Fmoc-Val-Cit-PAB
Cleavable Linker
     
Protease Cleavable Linker
    99.39%
Fmoc-Val-Cit-PAB-PNP
Cleavable Linker
     
Protease Cleavable Linker
    98.99%
N3-PEG4-C2-NHS ester  
Non-cleavable Linker
          98.94%
DBCO-amine
Cleavable Linker
            99.77%
Fmoc-8-amino-3,6-dioxaoctanoic acid
Cleavable Linker
            99.73%
DBCO-acid
Cleavable Linker
            99.63%
BS3 Crosslinker disodium  
Non-cleavable Linker
          98.00%
N-Hydroxysulfosuccinimide sodium  
Non-cleavable Linker
          ≥98.0%
Fmoc-NH-PEG4-CH2CH2COOH
Cleavable Linker
            99.92%
Fmoc-Gly-Gly-Phe-OH
Cleavable Linker
            99.49%
Vipivotide tetraxetan Ligand-Linker Conjugate  
Non-cleavable Linker
          99.95%
Boc-Dap-NE
Cleavable Linker
            99.92%
SPDB
Cleavable Linker
   
Disulfide Cleavable Linker
      98.82%
MC-Gly-Gly-Phe
Cleavable Linker
            99.05%
N-Butanoyl-L-homoserine lactone
Cleavable Linker
            ≥98.0%
DBCO-PEG5-NHS ester
Cleavable Linker
           
6-Maleimidohexanoic acid N-hydroxysuccinimide ester  
Non-cleavable Linker
          99.76%
Boc-NH-C6-Br  
Non-cleavable Linker
          ≥98.0%
sulfo-SPDB
Cleavable Linker
   
Disulfide Cleavable Linker
     
6-Azido-hexylamine
Cleavable Linker
            ≥98.0%
Boc-C16-COOH  
Non-cleavable Linker
         
NH2-PEG2-C2-Boc  
Non-cleavable Linker
          ≥98.0%
Azido-PEG2-C2-amine  
Non-cleavable Linker
         
Fmoc-Lys-OH hydrochloride  
Non-cleavable Linker
          99.22%
N3-PEG2-C2-NHS ester  
Non-cleavable Linker
          ≥98.0%
TCO-PEG4-NHS ester
Cleavable Linker
            99.58%
Gly-Gly-Gly-PEG4-azide
Cleavable Linker
           
Mal-amido-PEG8-C2-acid  
Non-cleavable Linker
          99.04%
N-Boc-PEG4-bromide
Cleavable Linker
            ≥98.0%
Boc-NH-PEG4-CH2CH2NH2
Cleavable Linker
            ≥98.0%
BS3 Crosslinker  
Non-cleavable Linker
         
H-Glu-OtBu  
Non-cleavable Linker
          ≥98.0%
Mal-PEG3-NHS ester  
Non-cleavable Linker
          99.45%
Azido-PEG7-amine  
Non-cleavable Linker
         
1-Boc-azetidine-3-carboxylic acid  
Non-cleavable Linker
          ≥98.0%
MC-Gly-Gly-Phe-Gly
Cleavable Linker
            98.94%
BMPS  
Non-cleavable Linker
          99.93%
Mal-​PEG4-​NHS ester  
Non-cleavable Linker
          99.10%
DBCO-Maleimide
Cleavable Linker
           
Bromo-PEG2-C2-azide  
Non-cleavable Linker
          98.10%
N3-PEG3-CH2CH2COOH  
Non-cleavable Linker
          ≥98.0%
Amino-PEG4-alcohol  
Non-cleavable Linker
          99.73%
Biotin-PEG1-NH2
Cleavable Linker
           
SPDMV      
Disulfide Cleavable Linker
     
N-Boc-PEG2-bromide
Cleavable Linker
           
N-Boc-PEG3-bromide
Cleavable Linker
            ≥98.0%
Methyl azetidine-3-carboxylate hydrochloride  
Non-cleavable Linker
          ≥98.0%
S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate
Cleavable Linker
   
Disulfide Cleavable Linker
     
Bis-​PEG2-​NHS ester  
Non-cleavable Linker
          ≥98.0%
Mal-C2-NHS ester  
Non-cleavable Linker
          99.30%
SPP
Cleavable Linker
   
Disulfide Cleavable Linker
     
NHS-SS-Ph
Cleavable Linker
   
Disulfide Cleavable Linker
     
Boc-Val-Cit-OH
Cleavable Linker
     
Protease Cleavable Linker
    ≥98.0%
Succinic anhydride  
Non-cleavable Linker
          ≥98.0%
Azetidin-3-ol hydrochloride  
Non-cleavable Linker
          ≥98.0%
N3-PEG3-C2-NHS ester  
Non-cleavable Linker
          99.91%
Boc-Gly-Gly-Phe-Gly-OH
Cleavable Linker
            99.62%
MC-Val-Ala-PAB-PNP
Cleavable Linker
     
Protease Cleavable Linker
    99.51%
BCN-PEG3-Biotin  
Non-cleavable Linker
         
NH2-PEG8-acid  
Non-cleavable Linker
          ≥98.0%
Fmoc-Val-Ala-PAB-OH
Cleavable Linker
     
Protease Cleavable Linker
    98.04%
Biotin-PEG2-acid  
Non-cleavable Linker
         
Fmoc-Val-Ala-PAB-PNP
Cleavable Linker
     
Protease Cleavable Linker
    98.06%
DBCO-CONH-S-S-NHS ester
Cleavable Linker
   
Disulfide Cleavable Linker
     
Mal-PEG6-NHS ester  
Non-cleavable Linker
          ≥98.0%
Azido-PEG6-amine  
Non-cleavable Linker
         
AMAS  
Non-cleavable Linker
         
Azido-PEG6-NHS ester
Cleavable Linker
            98.85%
Boc-Hyp-OH  
Non-cleavable Linker
          99.78%
Mal-PEG2-NHS ester  
Non-cleavable Linker
          98.06%
Fmoc-NH-PEG3-CH2CH2COOH
Cleavable Linker
            99.79%
Fmoc-NH-PEG2-CH2CH2COOH
Cleavable Linker
            99.61%
NHS-SS-biotin
Cleavable Linker
   
Disulfide Cleavable Linker
      ≥98.0%
PDEC-NB
Cleavable Linker
   
Disulfide Cleavable Linker
      99.69%
N3-C3-NHS ester  
Non-cleavable Linker
          99.46%
Mal-PEG1-acid  
Non-cleavable Linker
          99.40%
NH2-PEG5-OH  
Non-cleavable Linker
          ≥98.0%
Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP
Cleavable Linker
     
Protease Cleavable Linker
    98.42%
Mal-PEG2-VCP-NB
Cleavable Linker
     
Protease Cleavable Linker
    98.25%
N-Boc-PEG5-bromide
Cleavable Linker
           
Boc-Val-Cit-PAB-PNP
Cleavable Linker
     
Protease Cleavable Linker
    98.96%
PPC-NB      
Disulfide Cleavable Linker
      99.90%
Propargyl-PEG1-NHS ester  
Non-cleavable Linker
          ≥98.0%
Fmoc-PEA
Cleavable Linker
         
Phosphatase Cleavable Linker
Mal-PEG1-NHS ester
Cleavable Linker
            98.41%
N-Boc-PEG6-alcohol
Cleavable Linker
           
Azido-PEG8-NHS ester
Cleavable Linker
           
N3-PEG4-C2-Pfp ester  
Non-cleavable Linker
         
Propargyl-PEG2-amine  
Non-cleavable Linker
          99.64%
Fmoc-Asp-NH2
Cleavable Linker
            98.04%
DBCO-PEG3-oxyamine  
Non-cleavable Linker
          98.05%
20-(tert-Butoxy)-20-oxoicosanoic acid  
Non-cleavable Linker
         
Amino-PEG2-C2-acid
Cleavable Linker
            ≥98.0%
Amino-PEG3-C2-acid
Cleavable Linker
           
NH2-PEG6-Boc  
Non-cleavable Linker
         
Biotin-PEG3-aldehyde
Cleavable Linker
           
Cyclooctyne-O-NHS ester
Cleavable Linker
            ≥98.0%
Bis-PEG9-NHS ester
Cleavable Linker
           
Bis-PEG7-NHS ester
Cleavable Linker
            ≥98.0%
m-PEG7-CH2CH2COOH  
Non-cleavable Linker
          99.39%
Ald-Ph-NHS ester  
Non-cleavable Linker
          98.56%
m-PEG12-amine  
Non-cleavable Linker
          ≥98.0%
BCN-SS-NHS
Cleavable Linker
   
Disulfide Cleavable Linker
     
β-D-glucuronide-pNP-carbonate
Cleavable Linker
       
Glycosidase Cleavable Linker
  99.44%
CL2A
Cleavable Linker
            98.17%
Fmoc-NH-PEG6-CH2CH2COOH
Cleavable Linker
            99.29%
Azido-C6-OH
Cleavable Linker
           
Bis-PEG1-NHS ester  
Non-cleavable Linker
         
MC-Val-Ala-OH
Cleavable Linker
     
Protease Cleavable Linker
    99.68%
m-PEG2-Amine
Cleavable Linker
            99.58%
Mal-amido-PEG2-NHS ester  
Non-cleavable Linker
          99.32%
Fmoc-NH-PEG8-CH2CH2COOH
Cleavable Linker
           
N-Boc-PEG7-alcohol
Cleavable Linker
           
Propargyl-PEG4-NHS ester  
Non-cleavable Linker
         
Propargyl-C1-NHS ester  
Non-cleavable Linker
          99.78%
Aminoethyl-SS-propionic acid
Cleavable Linker
   
Disulfide Cleavable Linker
      98.03%
m-PEG8-Amine
Cleavable Linker
           
Mc-​Val-​Ala-​PAB
Cleavable Linker
     
Protease Cleavable Linker
    98.93%
Hydroxy-PEG3-(CH2)2-Boc  
Non-cleavable Linker
         
Fmoc-NH-PEG1-CH2COOH
Cleavable Linker
            99.91%
Azido-PEG9-amine  
Non-cleavable Linker
          98.52%
Propargyl-PEG2-acid  
Non-cleavable Linker
          ≥98.0%
NH2-PEG4-CH2CH2COOH
Cleavable Linker
            ≥98.0%
Bis-PEG13-NHS ester
Cleavable Linker
           
Mal-PEG4-Val-Cit-PAB-PNP
Cleavable Linker
     
Protease Cleavable Linker
    98.05%
Br-PEG4-C2-Boc
Cleavable Linker
            ≥98.0%
N-Boc-cis-4-hydroxy-L-proline  
Non-cleavable Linker
          ≥98.0%
Boc-Val-Cit-PAB
Cleavable Linker
     
Protease Cleavable Linker
    99.99%
Mc-Val-Cit-PAB-Cl
Cleavable Linker
     
Protease Cleavable Linker
   
Amino-PEG5-C2-acid  
Non-cleavable Linker
         
N-Boc-diethanolamine
Cleavable Linker
            99.95%
Fmoc-Gly-Gly-OH
Cleavable Linker
            99.98%
Mal-Val-Ala-PABA-cGAMP
Cleavable Linker
            98.57%
Mc-Gly-Gly-Phe-Gly-PAB-OH TFA
Cleavable Linker
           
Azido-PEG4-Val-Cit-PAB-OH
Cleavable Linker
     
Protease Cleavable Linker
    ≥98.0%
Propargyl-PEG3-NHS ester
Cleavable Linker
           
NH2-PEG6-CH2CH2COOH
Cleavable Linker
           
H-Hyp-OMe hydrochloride  
Non-cleavable Linker
         
Fluorescein-DBCO  
Non-cleavable Linker
         
DBCO-PEG4-Maleimide
Cleavable Linker
            98.02%
TCO-SS-amine
Cleavable Linker
   
Disulfide Cleavable Linker
     
Boc-NH-ethyl-SS-propionic acid
Cleavable Linker
   
Disulfide Cleavable Linker
     
β-Estradiol-6-CMO-PEG3-biotin
Cleavable Linker
           
Mc-Gly-Gly-Phe-Gly-PAB-OH
Cleavable Linker
            98.03%
N3-C2-NHS ester  
Non-cleavable Linker
          ≥98.0%
Azide-PEG5-Tos
Cleavable Linker
            ≥98.0%
Amino-PEG6-alcohol  
Non-cleavable Linker
         
BCN-PEG4-acid
Cleavable Linker
            99.27%
Boc-NH-PEG4-CH2COOH
Cleavable Linker
           
Bis-PEG5-NHS ester
Cleavable Linker
           
DBCO-PEG4-DBCO
Cleavable Linker
           
SNPB
Cleavable Linker
   
Disulfide Cleavable Linker
      98.01%
(2R,4S)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid  
Non-cleavable Linker
          ≥98.0%
Hydroxy-PEG2-(CH2)2-Boc  
Non-cleavable Linker
         
m-PEG6-NHS ester  
Non-cleavable Linker
         
Mal-PEG2-acid  
Non-cleavable Linker
         
Boc-C14-COOH  
Non-cleavable Linker
          ≥98.0%
2-Aminoethyl-mono-amide-DOTA-tris(tBu ester)
Cleavable Linker
            ≥98.0%
Azido-PEG4-CH2-Boc
Cleavable Linker
           
DBCO-Val-Cit-PABC-PNP
Cleavable Linker
     
Protease Cleavable Linker
   
Mal-PEG1-Val-Cit-PABC-OH
Cleavable Linker
     
Protease Cleavable Linker
   
DBCO-​C6-​acid  
Non-cleavable Linker
         
Gly-Gly-Gly-PEG4-DBCO
Cleavable Linker
            98.35%
1-Boc-azetidine-3-yl-methanol  
Non-cleavable Linker
          99.89%
Azido-PEG8-acid  
Non-cleavable Linker
          ≥98.0%
Me-triacetyl-β-D-glucopyranuronate-Ph-CH2OH-Fmoc
Cleavable Linker
       
Glycosidase Cleavable Linker
  98.84%
(2-pyridyldithio)-PEG1-hydrazine
Cleavable Linker
   
Disulfide Cleavable Linker
      99.30%
PC Mal-NHS carbonate ester
Cleavable Linker
           
Fmoc-NH-PEG4-CH2COOH
Cleavable Linker
            99.11%
SIA Crosslinker  
Non-cleavable Linker
         
Azido-PEG5-acid  
Non-cleavable Linker
          ≥98.0%
DBCO-PEG3-SS-NHS ester
Cleavable Linker
   
Disulfide Cleavable Linker
     
Azide-PEG3-Tos  
Non-cleavable Linker
          98.89%
Tetrazine-PEG4-amine hydrochloride
Cleavable Linker
           
N-(5-Hydroxypentyl)maleimide  
Non-cleavable Linker
          99.89%
Azido-PEG6-alcohol  
Non-cleavable Linker
         
m-PEG10-alcohol  
Non-cleavable Linker
         
4-Methyl-4-(methyldisulfanyl)pentanoic acid
Cleavable Linker
   
Disulfide Cleavable Linker
      99.97%
Mal-PEG2-Val-Cit-PABA
Cleavable Linker
     
Protease Cleavable Linker
    ≥98.0%
Aminooxy-PEG2-azide  
Non-cleavable Linker
         
TCO-PEG4-DBCO
Cleavable Linker