1. GPCR/G Protein Neuronal Signaling
  2. Adrenergic Receptor
  3. Nipradolol

Nipradolol  (Synonyms: KT 210; K 351; Hypadil)

目录号: HY-106523
产品使用指南

Nipradolol (KT-210; K-351) 是一种有效的 α-1-肾上腺素能受体的阻滞剂。Nipradolol 还抑制白化兔模型中 Phenylephrine (HY-B0769) 诱导的眼压升高 (IOP)。Nipradolol 抑制去甲肾上腺素 (NA) 引起的肌肉收缩,对犬冠状动脉也有血管扩张剂活性。

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Nipradolol Chemical Structure

Nipradolol Chemical Structure

CAS No. : 81486-22-8

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nipradolol (KT-210; K-351) is a potent blocker of alpha-1-adrenergic receptors. Nipradolol inhibits the increase of intraocular pressure (IOP) in an albino rabbit model induced by Phenylephrine (HY-B0769). Nipradolo suppresses the noradrenaline (NA)-induced muscles contraction, also exhibits vasodilator activity on the dog coronary artery[1][2].

IC50 & Target[2]

α1-adrenergic receptor

 

体外研究
(In Vitro)

Nipradolol (1 μM; 10 分钟) 抑制钾诱导的犬肌肉收缩,ID50 值为 0.8 μM[1]
Nipradolol (1 μM; 10 分钟) 降低静息张力,抑制近端区钠诱导的收缩[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Nipradolol (0.125%, 0.25%, 0.5%; 静脉注射; 单剂量) 以浓度依赖的方式抑制兔眼眼压的增加[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

326.34

Formula

C15H22N2O6

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Nipradolol
目录号:
HY-106523
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