2. GPCR/G Protein Neuronal Signaling
  3. Neuropeptide Y Receptor
  4. NNC0165-1273 TFA

NNC0165-1273 (TFA) 是 NNC0165-1273 (HY-P11291) 的三氟乙酸盐。NNC0165-1273 是一种肠激素肽 YY (PYY3-36) 类似物。NNC0165-1273 对 Y2 receptor 的亲和力显著高于 Y1、Y4 和 Y5 受体。NNC0165-1273 具有强效的厌食作用，并通过产生早饱感显著减少夜间和生长素释放肽诱导的食物摄入量。NNC0165-1273 可抑制生长素释放肽诱导的 NPY/AgRP 神经元中 cFos 的表达。NNC0165-1273 可用于抗肥胖疗法研究。

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Custom Peptide Synthesis

NNC0165-1273 TFA

NNC0165-1273 TFA Chemical Structure

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Other Forms of NNC0165-1273 TFA:

NNC0165-1273 TFA 相关抗体

Top Publications Citing Use of Products

查看 Neuropeptide Y Receptor 亚型特异性产品:

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NPY Y1 receptor NPY Y2 receptor NPY Y4 receptor NPY Y5 receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NNC0165-1273 (TFA) is the trifluoroacetic acid of NNC0165-1273 (HY-P11291). NNC0165-1273 is an analog of gut hormone peptide YY (PYY3-36). NNC0165-1273 has a superior affinity for Y2 receptor over Y1, Y4, and Y5 receptor. NNC0165-1273 has a potent anorectic effect and significantly reduces nighttime and ghrelin-induced food intake by producing early satiety. NNC0165-1273 inhibits ghrelin-induced cFos expression in NPY/AgRP neurons. NNC0165-1273 can be used for antiobesity therapies research[1].

分子量

4136.54 (free base)

Formula

C186H280N54O54·xC2HF3O2
性状

固体

Sequence

Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Trp-Val-Thr-Arg-Gln-{β-homoArg}-Phe-NH2
Sequence Shortening

IKPEAPGEDASPEELNRYYASLRHYLNWVTRQ-{β-homoArg}-Y-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

NNC0165-1273 TFA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NNC0165-1273Neuropeptide Y ReceptorNPY receptorPYY3-36Y2 receptorAnorecticFood intakeNPY/AgRP neuronsAntiobesity therapiesInhibitorinhibitorinhibit

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产品名称：
NNC0165-1273 TFA
目录号：
HY-P11291A
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