1. Apoptosis
  2. Apoptosis
  3. NP137

NP137 是一种靶向 Netrin-1 的人源 IgG1 单克隆抗体 (mAb)。NP137 可抑制 netrin-1 与其受体 UNC5H2 的结合 (IC50: 0.5 nM)。NP137 可激活 caspase 3 来诱导细胞凋亡 (Apoptosis)。NP137 可用于实体瘤和血液系统恶性肿瘤的研究。推荐同型对照:Human IgG1 kappa,Isotype Control (HY-P99001)。

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规格 价格 是否有货 数量
1 mg ¥2500
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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NP137 is a human IgG1 monoclonal antibody (mAb) targeting Netrin-1. NP137 inhibits the binding of netrin-1 to its receptor UNC5H2 (IC50: 0.5 nM). NP137 activates caspase 3 to induce apoptosis. NP137 can be used in solid tumors and hematologic malignancies research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001)[1].

同型

Human IgG1 kappa

推荐同型对照抗体
反应种属

Human

IC50 & Target

Netrin-1

基因 ID

9423  [NCBI]

Accession
应用

ELISA, FACS, Functional assay

偶联物

Unconjugated

复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.

性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Biological Activity
  • Immobilized Netrin-1 (His Tag) can bind NP137. The EC50 for this effect is 12.2 ng/mL.
纯度 & 产品资料

纯度: 99.58%

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inquiry Information

产品名称:
NP137
目录号:
HY-P991427
需求量: