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  2. NY-ESO-1 (87-111)

NY-ESO-1 (87-111) 

目录号: HY-P2507
产品使用指南

NY-ESO-1 (87-111) 是一种泛 MHC II 类限制性肽序列。NY-ESO-1 (87-111) 与多个 HLA-DR 和 HLA-DP4 分子结合,并在 HLA-DR 和 HLA-DP4 分子存在的情况下刺激 Th1 型和 Th-2/Th0 型 CD4+ T 细胞。

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Custom Peptide Synthesis

NY-ESO-1 (87-111) Chemical Structure

NY-ESO-1 (87-111) Chemical Structure

CAS No. : 508230-31-7

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Description

NY-ESO-1 (87-111) is a pan-MHC class II-restricted peptide sequence. NY-ESO-1 (87-111) binds to multiple HLA-DR and HLA-DP4 molecules, and stimulates Th1-type and Th-2/Th0-type CD4+ T cells when presented in the context of HLA-DR and HLA-DP4 molecules[1].

Molecular Weight

2869.40

Formula

C₁₃₁H₂₀₆N₃₂O₃₆S₂

CAS No.

508230-31-7

Sequence Shortening

LLEFYLAMPFATPMEAELARRSLAQ

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

NY-ESO-1 (87-111)OthersHLA-DRHLADP4pan-MHCTh1Th-2Th0CD4+T-cellsInhibitorinhibitorinhibit

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产品名称:
NY-ESO-1 (87-111)
目录号:
HY-P2507
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