Octacosane  (Synonyms: 二十八烷; n-Octacosane; NSC 5549)

Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC₅₀ concentration of 7.2 mg/l^[1][2][3].

Octacosane (12.5-100 μg/ml; 18 h) displays strong cytotoxic activity on B16F10-Nex2 cells, with an IC₅₀ value of 41.08 μg/ml^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Octacosane (500 μg; injected at peripheral sites in relation to the original cell grafting; daily; 35 days) results in a significant delay of tumor progression with a significant antitumor effect^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

394.76

C₂₈H₅₈

630-02-4

固体

White to off-white

二十八烷

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Carlos R Figueiredo, et al. Pyrostegia venusta heptane extract containing saturated aliphatic hydrocarbons induces apoptosis on B16F10-Nex2 melanoma cells and displays antitumor activity in vivo. Pharmacogn Mag. 2014 Apr;10(Suppl 2):S363-76.  [Content Brief]

  [2]. S Rajkumar, et al. Mosquitocidal activities of octacosane from Moschosma polystachyum Linn (lamiaceae). J Ethnopharmacol. 2004 Jan;90(1):87-9.  [Content Brief]

  [3]. Sameh S M Soliman, et al. Effective targeting of breast cancer cells (MCF7) via novel biogenic synthesis of gold nanoparticles using cancer-derived metabolites. PLoS One. 2020 Oct 6;15(10):e0240156.  [Content Brief]