Ornipressin acetate  (Synonyms: POR-8 acetate)

Ornipressin (POR-8) acetate is a potent vasoconstrictor, hemostatic and renal agent. Ornipressin acetate is a vasopressin agonist specific for the V1 receptor. Ornipressin acetate can be used as a local vasoconstrictor. Ornipressin acetate can reverse the hypotension associated with combine general/epidural anesthesia. Ornipressin acetate has antidiuretic activity. Ornipressin acetate decreases renal vascular resistance and increases renal blood flow in renal failure model^[1][2][3][4].

1042.19 (free base)

C₄₇H₆₇N₁₃O₁₄S₂

914453-98-8

固体

White to off-white

Cys-Tyr-Phe-Gln-Asn-Cys-Pro-{Orn}-Gly-NH2 (Disulfide bridge: Cys1-Cys6)

CYFQNCP-{Orn}-G-NH2 (Disulfide bridge: Cys1-Cys6)

鸟氨酸加压素醋酸盐

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. De Kock M, et al. Ornipressin (Por 8): An efficient alternative to counteract hypotension during combined general/epidural anesthesia. Anesth Analg. 2000 Jun;90(6):1301-7.  [Content Brief]

  [2]. Fruhstorfer H, et al. Dose-response relation of ornipressin with regard to vasoconstriction in human skin. Br J Anaesth. 1994 Aug;73(2):220-4.  [Content Brief]

  [3]. Kam, P. C., & Tay, T. M. (1998). The pharmacology of ornipressin (POR-8): a local vasoconstrictor used in surgery. European journal of anaesthesiology, 15(2), 133–139.  [Content Brief]

  [4]. Lenz, K., et al., (1991). Ornipressin in the treatment of functional renal failure in decompensated liver cirrhosis. Effects on renal hemodynamics and atrial natriuretic factor. Gastroenterology, 101(4), 1060–1067.  [Content Brief]