1. GPCR/G Protein Neuronal Signaling
  2. 5-HT Receptor
  3. Osemozotan hydrochloride

Osemozotan hydrochloride  (Synonyms: MKC242)

目录号: HY-100426A
产品使用指南

Osemozotan hydrochloride (MKC242) 是选择性的 5-HT1A 受体激动剂。Osemozotan hydrochloride 减少在小鼠体内 MAMP 诱导的 c-Fos 阳性细胞数量。Osemozotan hydrochloride 可用于抑郁症的研究。

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Osemozotan hydrochloride Chemical Structure

Osemozotan hydrochloride Chemical Structure

CAS No. : 137275-80-0

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生物活性

Osemozotan hydrochloride (MKC242) is a selective 5-HT1A receptor agonist. Osemozotan hydrochloride decreases the number of c-Fos-positive cells caused by MAMP in mice. Osemozotan hydrochloride can be used for the research of depressive disorder[1][2].

体内研究
(In Vivo)

Osemozotan hydrochloride (1 mg/kg; i.p.; 20 min after picrotoxin treatment) ameliorates picrotoxin-induced decrease in female preference with the combination of (+)-SKF-10,047[1].
Osemozotan hydrochloride (1 mg/kg; i.p.; once) decreases the number of c-Fos-positive cells caused by MAMP[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CD-1 mice with picrotoxin-induced decrease in female preference[1]
Dosage: 1 mg/kg
Administration: Intraperitoneal injection; 1 mg/kg; 20 min after picrotoxin treatment
Result: Ameliorated the picrotoxin-induced decrease in the female preference by co-administration WITH (+)-SKF-10,047 (5 mg/kg). Showed no effect on the picrotoxin-induced decrease in the female preference when treated alone.
Animal Model: ICR mice with MAMP injection[2]
Dosage: 1 mg/kg
Administration: Intraperitoneal injection; 1 mg/kg; once
Result: Significantly decreased the number of c-Fos-positive cells induced by MAMP in the medial prefrontal cortex and striatum, but did not change the number of c-Fos-positive cells.
分子量

379.83

Formula

C19H22ClNO5

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Osemozotan hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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