2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. (p-Iodo-Phe7)-ACTH (4-10)

(p-Iodo-Phe7)-ACTH (4-10) 是肾上腺皮质激素 (ACTH) 的衍生物，由垂体前腺产生和分泌。(p-Iodo-Phe7)-ACTH (4-10) 作为黑素皮质素 (MC) 受体拮抗剂，抑制 α-黑素细胞刺激激素 (α-MSH) 诱导的大鼠过度梳理行为。

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Custom Peptide Synthesis

(p-Iodo-Phe7)-ACTH (4-10) Chemical Structure

(p-Iodo-Phe7)-ACTH (4-10) Chemical Structure

CAS No. : 159600-82-5

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(p-Iodo-Phe7)-ACTH (4-10) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(p-Iodo-Phe7)-ACTH (4-10) is a adrenocorticotrophic hormone (ACTH) derivative, which is produced and secreted by the anterior pituitary gland. (p-Iodo-Phe7)-ACTH (4-10) serves as a melanocortin (MC) receptor antagonist and inhibits α-melanocyte-stimulating hormone (α-MSH)-induced excessive grooming behavior in rats[1].

体外研究
(In Vitro)

(p-Iodo-Phe7)-ACTH (4-10) (1 μM) exhibits inhibition of α-MSH-induced (1 nM-1 μM) cAMP accumulation in 293 HEK cells expressing either the rat melanocortin MC3, human melanocortin MC4 or ovine melanocortin MC5 receptor[1].
[Phe-I7]ACTH(4-10) has higher affinity for the MC3, MC4, and MC5 receptors but lower for the MC1 compared to ACTH(4-10)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(p-Iodo-Phe7)-ACTH (4-10) 相关抗体:
体内研究
(In Vivo)

(p-Iodo-Phe7)-ACTH (4-10) (15 μg per animal; i.c.v.; single dose) blocks the a-MSH-induced excessive grooming behavior in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (150 g)[1]
Dosage: 1.5 or 15 μg per animal, mixed with 1.5 μg α-MSH or not
Administration: Intracerebroventricular injection; one week prior to the experiment
Result: Didn’t induce excessive grooming behavior by single dose.
Inhibited the induction of excessive grooming behavior by a-MSH.
分子量

1087.98

Formula

C44H58IN13O10S
CAS 号
Sequence Shortening

MEH-{p-Iodo-Phe}-RWG
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(p-Iodo-Phe7)-ACTH (4-10) 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

(p-Iodo-Phe7)-ACTH (4-10)159600-82-5Melanocortin ReceptorMC Receptora-MSHa-melanocyte-stimulating hormoneanterior pituitary glandInhibitorinhibitorinhibit

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