2. Epigenetics
  3. Protein Arginine Deiminase
  4. AFM-30a

AFM-30a 是一种有效的蛋白质精氨酸脱亚胺酶 2 (PAD2) 抑制剂，具有出色的 PAD2 选择性。AFM-30a 与 PAD2 结合的 EC50 值为 9.5 μM。AFM-30a 还抑制 H3 瓜氨酸化，EC50 值为 0.4 μM。AFM-30a 可用于某些癌症和多种自身免疫性疾病如类风湿性关节炎 (RA)、多发性硬化症、狼疮和溃疡性结肠炎的研究。

该游离形式化合物不稳定，推荐具有相同生物学活性的稳定盐形式 AFM-30a hydrochloride。

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AFM-30a Chemical Structure

AFM-30a Chemical Structure

CAS No. : 2095107-57-4

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AFM-30a 的其他形式现货产品:

Customer Review

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AFM-30a 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AFM-30a is a potent protein arginine deiminase 2 (PAD2) inhibitor and has excellent PAD2-selectivity. AFM-30a binds to PAD2 with an EC50 value of 9.5 μM. AFM-30a also inhibits H3 citrullination with an EC50 value of 0.4 μM. AFM-30a can be used for the research of certain cancers and a variety of autoimmune diseases including rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis[1].

IC50 & Target[1]

PAD2

 

体外研究
(In Vitro)

AFM-30a (compound 30a; 25 μM) has good potency to enter HEK293T/PAD2 cells and covalent modify PAD2 with an EC50 of 9.5 μM[1].
AFM-30a shows good ability to inhibit H3 citrullination with an EC50 of 0.4 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AFM-30a 相关抗体:

Cell Viability Assay[1]

Cell Line: HEK293T/PAD2 cells
Concentration: Various concentrations
Incubation Time: 24 h
Result: Exhibited low cytotoxicity for cells.
体内研究
(In Vivo)

AFM-30a suppresses NLRP3 signaling and decreases airway remodeling in PAD2-/-transgenic mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

466.51

Formula

C24H27FN6O3
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥96.0%

COA (267 KB)

产品使用指南 (1538 KB)
参考文献

AFM-30a 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AFM-30a2095107-57-4Protein Arginine DeiminasePeptidylarginine Deiminaseprotein arginine deiminase 2 (PAD2)H3 citrullinationcancerautoimmune diseasesrheumatoid arthritis (RA)multiple sclerosislupusulcerative colitisHEK293T cellsInhibitorinhibitorinhibit

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产品名称：
AFM-30a
目录号：
HY-125099
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