2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. PCSK9 degrader 1

PCSK9 degrader 1 

目录号: HY-130245 纯度: 98.26%
COA 产品使用指南

摩尔计算器

PCSK9 degrader 1 (Compound 16) 是 PCSK9 的小分子配体，对 PCSK9 具有高亲和力，其 Ki 值为 107 nM，可参与蛋白质与低密度脂蛋白受体的蛋白质相互作用。

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PCSK9 degrader 1 Chemical Structure

PCSK9 degrader 1 Chemical Structure

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1 mg ￥7000
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PCSK9 degrader 1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PCSK9 degrader 1 (Compound 16) is a small molecule ligand for proprotein convertase substilisin-like/kexin type 9 (PCSK9) and shows high affinity to PCSK9 with a Ki of 107 nM. PCSK9 degrader 1 can involve in a protein-protein interaction with the low-density lipoprotein (LDL) receptor[1].

IC50 & Target

Ki: 107 nM (PCSK9)[1]
体外研究
(In Vitro)

PCSK9 degrader 1 (Compound 16; 1.25-20 μM; 24 hours; HEK293 cells) treatment shows a clear concentration-dependent degradation of both the pro and mature form of PCSK9 yielding a half-maximal degradation concentration of 4.8 and 3.4 μM, as well as a maximum percentage of degradation at 20 μM of 58% and 61%, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PCSK9 degrader 1 相关抗体:

Western Blot Analysis[1]

Cell Line: HEK293 cells
Concentration: 1.25 μM, 2.5 μM, 5 μM, 10 μM or 20 μM
Incubation Time: 24 hours
Result: Showed a clear concentration-dependent degradation of both the pro and mature form of PCSK9 yielding a half-maximal degradation concentration of 4.8 and 3.4 μM, as well as a maximum percentage of degradation at 20 μM of 58% and 61%, respectively.
分子量

1077.22

Formula

C53H69FN8O13S
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

PCSK9 degrader 1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PCSK9 degrader 1Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesInhibitorinhibitorinhibit

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产品名称：
PCSK9 degrader 1
目录号：
HY-130245
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