2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. PDE4-IN-11

PDE4-IN-11 是磷酸二酯酶同工酶 4 (PDE4) 抑制剂。PDE4-IN-11 具有高效的支气管扩张和抗炎特性，可用于阻塞性或炎症性气道疾病的研究。

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PDE4-IN-11 Chemical Structure

PDE4-IN-11 Chemical Structure

CAS No. : 524734-30-3

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PDE4-IN-11 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PDE4-IN-11 is an inhibitor of phosphodiesterase isoenzyme 4 (PDE4). PDE4-IN-11 displays highly effective bronchodilatory and anti-inflammatory properties, can be used for obstructive or inflammatory airway diseases research[1][2][3].

IC50 & Target

PDE4

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
PBMC EC50
126 nM
Compound: 53
Anti-inflammatory activity against human PBMCs assessed as reduction in LPS-induced TNF-alpha release by ELISA analysis
Anti-inflammatory activity against human PBMCs assessed as reduction in LPS-induced TNF-alpha release by ELISA analysis
[PMID: 33569941]
体外研究
(In Vitro)

PDE4-IN-11 (example 12) exerts function in the monocrotaline reversal model of pulmonary hypertension[2].
PDE4-IN-11 (compound A1) displays anti­inflammatory, anti-airways hyperreactivity and bronch odilator properties. PDE4-IN-11 also possesses immunosuppressive and TNFα secretion inhibitory activities[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PDE4-IN-11 相关抗体:
分子量

350.39

Formula

C21H19FN2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PDE4-IN-11 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDE4-IN-11524734-30-3Phosphodiesterase (PDE)naphthyridinesbronchodilatoryanti-inflammatoryairway diseaseshuman pulmonary hypertensionTNFα secretion inhibitionairways hyperreactivitybronch odilatorInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-150060
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