2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. PDI
  4. PDI-IN-2

PDI-IN-2 (Compound 22) 是一种 PDI 或重组 PDI 抑制剂，IC50 值分别为 0.62 和 0.63 μM。PDI-IN-2 具有抗肿瘤活性。

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PDI-IN-2

PDI-IN-2 Chemical Structure

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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PDI-IN-2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PDI-IN-2 (Compound 22) is a PDI or recombinant PDI inhibitor with IC50 values of 0.62 and 0.63 μM, respectively. PDI-IN-2 has antitumor activity[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
8.95 μM
Compound: 22
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin assay
[PMID: 38381886]
EA.hy 926 IC50
5.42 μM
Compound: 22
Cytotoxicity against human EA.hy 926 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin assay
Cytotoxicity against human EA.hy 926 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin assay
[PMID: 38381886]
MDA-MB-231 IC50
4.42 μM
Compound: 22
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin assay
[PMID: 38381886]
Platelet IC50
0.5 μM
Compound: 22
Antiplatelet activity in human platelets assessed as inhibition of collagen-induced platelet aggregation by turbidimetric analysis
Antiplatelet activity in human platelets assessed as inhibition of collagen-induced platelet aggregation by turbidimetric analysis
[PMID: 38381886]
Platelet IC50
1.54 μM
Compound: 22
Antiplatelet activity in human platelets assessed as inhibition of U46619-induced platelet aggregation by turbidimetric analysis
Antiplatelet activity in human platelets assessed as inhibition of U46619-induced platelet aggregation by turbidimetric analysis
[PMID: 38381886]
RPMI-8226 IC50
0.66 μM
Compound: 22
Cytotoxicity against human RPMI-8226 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin assay
Cytotoxicity against human RPMI-8226 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin assay
[PMID: 38381886]
RPMI-8226 IC50
48 nM
Compound: 22
Cytotoxicity against human RPMI-8226 cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay
Cytotoxicity against human RPMI-8226 cells assessed as reduction in cell viability incubated for 72 hrs by resazurin assay
[PMID: 38381886]
U-87MG ATCC IC50
3.22 μM
Compound: 22
Cytotoxicity against human U87 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin assay
Cytotoxicity against human U87 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin assay
[PMID: 38381886]
分子量

520.44

Formula

C24H24O13
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PDI-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDI-IN-2PDIProtein Disulfide IsomerasesInhibitorJuglonePlatelet-Enhanced Cancer Cellinhibitorinhibit

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Inquiry Information

产品名称：
PDI-IN-2
目录号：
HY-163351
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