2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Immunology/Inflammation
  3. PDI Interleukin Related
  4. PDIA1-IN-1

PDIA1-IN-1 是一种蛋白质二硫键异构酶 1 (PDIA1) 抑制剂。PDIA1-IN-1 能够抑制 NLRP3 炎症小体的组装和活性，其 IC50 值为 1 μM。PDIA1-IN-1 可以减少 IL-1β 的分泌。PDIA1-IN-1 可用于炎症和神经系统疾病的研究。

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PDIA1-IN-1

PDIA1-IN-1 Chemical Structure

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Customer Review

PDIA1-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PDIA1-IN-1 is a protein disulfide isomerase 1 (PDIA1) inhibitor. PDIA1-IN-1 can inhibit NLRP3 inflammasome assembly and activity, with an IC50 value of 1 μM. PDIA1-IN-1 can reduce IL-1β secretion. PDIA1-IN-1 can be used for the researches of inflammation and neurological disease[1].

IC50 & Target

PDI1

 

IL-1β

 

体外研究
(In Vitro)

PDIA1-IN-1 (Compound P11) 可抑制脂多糖 (HY-D1056) 预处理的 THP1 单核细胞中 ASC-GFP 斑点的形成，其 IC50 值为 890 nM[1]。
PDIA1-IN-1 (1.25-2.5 μM, 2 h) 以剂量依赖性方式在脂多糖预处理的 THP1 单核细胞中与 PDIA1 结合[1]。
PDIA1-IN-1 (5-10 μM, 1-16 h) 可减少脂多糖预处理的 THP1 单核细胞中 IL-1β 的分泌[1]。
PDIA1-IN-1 (1 μM, 2 h) 可恢复脂多糖预处理的 THP1 单核细胞的活力[1]。
PDIA1-IN-1 (10 μM, 1 h) 会降低脂多糖预处理的 THP1 单核细胞的活力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PDIA1-IN-1 相关抗体:

Western Blot Analysis[1]

Cell Line: LPS-primed THP1 monocytes
Concentration: 1.25 and 2.5 μM
Incubation Time: 2 h
Result: Dose-dependently engaged PDIA.
分子量

569.67

Formula

C29H35N3O7S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PDIA1-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDIA1-IN-1PDIInterleukin RelatedProtein Disulfide IsomerasesILProtein disulfide isomeraseNLRP3IL-1βTHP1Inhibitorinhibitorinhibit

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产品名称：
PDIA1-IN-1
目录号：
HY-175484
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