1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. iGluR
  3. PEAQX

PEAQX(NVP-AAM 077)是NMDA受体NR2A选择性高效拮抗剂,IC50值为270nM。

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PEAQX Chemical Structure

PEAQX Chemical Structure

CAS No. : 459836-30-7

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PEAQX 的其他形式现货产品:

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Top Publications Citing Use of Products

    PEAQX purchased from MCE. Usage Cited in: Neuroscience. 2018 Nov 1;391:1-12.  [Abstract]

    PP2 and NVP-AAM077 pretreatment decreases the expression level of Cleaved Caspase-3 significantly.
    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    PEAQX(NVP-AAM 077) is a potent and orally active NMDA antagonist with a 15-fold preference for human NMDA receptors with the 1A/2A(IC50=270 nM), rather than 1A/2B(29,600 nM). IC50 value: 270 nM(hNMDA A1/A2) [1] Target: NR2A antagonist in vitro: PEAQX has a high binding affinity for NMDA receptors (IC50=8 nM), and a functional preference in excess of 100-fold for hNMDA 1A/2A (IC50=of 270 nM) over 1A/2B receptors (IC50=29,600 nM) [1]. in vivo: PEAQX is practically inactive in Xenopus oocytes expressing hNMDA 1A/2B receptors, displays an ED50 value of 23 mg/kg in the MES test [1]. Sprague-Dawley rats were treated on PN7, PN9, and PN11 with PCP (10 mg/kg), PEAQX (NR2A-preferring antagonist; 10, 20, or 40 mg/kg), or ifenprodil (selective NR2B antagonist; 1, 5, or 10 mg/kg) and sacrificed for measurement of caspase-3 activity (an index of apoptosis) or allowed to age and tested for locomotor sensitization to PCP challenge on PN28-PN35. PCP or PEAQX on PN7, PN9, and PN11 markedly elevated caspase-3 activity in the cortex; ifenprodil showed no effect. Striatal apoptosis was evident only after subchronic treatment with a high dose of PEAQX (20 mg/kg). Animals treated with PCP or PEAQX on PN7, PN9, and PN11 showed a sensitized locomotor response to PCP challenge on PN28-PN35 [2].

    分子量

    454.21

    Formula

    C17H17BrN3O5P

    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    溶解性数据
    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    In Vivo:

    以下溶解方案源自文献,仅供参考,建议您先取少量样品进行尝试。

    • 方案 一

      PEAQX is dissolved in DMSO and diluted with sterile saline[3].

    动物溶解方案计算器
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    给药剂量

    mg/kg

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    动物数量

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    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料
    参考文献
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    产品名称:
    PEAQX
    目录号:
    HY-12294
    需求量: