2. Anti-infection
  3. Bacterial
  4. Peceleganan

Peceleganan (PL-5) 是一种人工抗菌天蚕素 A (1-10) × 蜂毒素 B (3-18) 杂化 (10+16) 肽类似物。Peceleganan 抑制伤口感染。

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Custom Peptide Synthesis

Peceleganan Chemical Structure

Peceleganan Chemical Structure

CAS No. : 850761-47-6

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规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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Peceleganan 的其他形式现货产品:

Customer Review

Other Forms of Peceleganan:

Peceleganan 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Peceleganan (PL-5) is an artificial antimicrobial cecropin A (1-10) × melittin B (3-18) hybrid (10+16)-peptide analogue. Peceleganan inhibits wound infection[1].

体外研究
(In Vitro)

Peceleganan (24 h) 具有抗菌活性，对 E. coli ATCC 25922、S. pneumonia ATCC 49619、K. pneumonia ATCC 700603、S. aureus ATCC 25923、S. epidermidis ATCC 12228 和 P. aeruginosa ATCC 27853 的MIC 值分别为 2、2、4、4、4 和 8 μM[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Peceleganan 相关抗体:
体内研究
(In Vivo)

Peceleganan (0.4 and 0.75 mg/mL for 100 μL; transdermal; twice daily for 3 days) acetate 在小鼠感染模型中抑制 Staphylococcus aureus[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR male mice (20-25 g), S. aureus ATCC 25923 wound infection model[2]
Dosage: 0.4 and 0.75 mg/mL for 100 μL
Administration: Transdermal administration, twice daily for 3 days
Result: Significantly reduced the amount of bacteria.
分子量

2933.50

Formula

C₁₃₈H₂₂₆N₃₆O₃₄
CAS 号
Sequence Shortening

Ac-KWKSFLKTFKSAAKTVLHTALKAISS-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

Peceleganan 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Peceleganan850761-47-6PL-5PL5PL 5Bacterialantimicrobialcecropin Amelittin Bwound infectionInhibitorinhibitorinhibit

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目录号：
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