2. Anti-infection MAPK/ERK Pathway Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Apoptosis
  3. Bacterial p38 MAPK Reactive Oxygen Species (ROS) Apoptosis Caspase
  4. Periplanetasin-4

Periplanetasin-4 是一种可从美洲蟑螂 (Periplaneta americana) 中提取的抗菌肽。Periplanetasin-4 减少细胞圆化和凋亡 (apoptosis)。Periplanetasin-4 阻断 Clostridium difficile toxin A 诱导的 ROS 产生以及下游 p38 MAPK 和 p21 的激活。Periplanetasin-4 显著增加 Candida albicans ATCC 90028 细胞中的线粒体钙水平，降低 DPH 荧光强度，并引发液泡功能障碍。Periplanetasin-4 显著改善小鼠肠道中毒素 A 诱导的黏膜损伤。Periplanetasin-4 可用于结肠炎的研究。

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Periplanetasin-4

Periplanetasin-4 Chemical Structure

CAS No. : 2206807-06-7

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Periplanetasin-4 相关抗体

Top Publications Citing Use of Products

查看 p38 MAPK 亚型特异性产品:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Periplanetasin-4 is an antimicrobial peptide that can be derived from the American cockroach (Periplaneta americana). Periplanetasin-4 reduces cell rounding and apoptosis. Periplanetasin-4 blocks Clostridium difficile toxin A-induced ROS production and the activation of downstream p38 MAPK and p21. Periplanetasin-4 significantly increases mitochondrial calcium level, reduces DPH fluorescence intensity and vacuolar dysfunction in Candida albicans ATCC 90028 cells. Periplanetasin-4 significantly ameliorates toxin A-induced mucosal damage in the mouse gut. Periplanetasin-4 can be used for the study of colitis[1][2].

体外研究
(In Vitro)

Periplanetasin-4 (100 μg/mL, 48 h) 显著挽救 HT29 细胞中由 Clostridium difficile toxin A 诱导的细胞活力丧失，并减少细胞圆化[1]。
Periplanetasin-4 (100 μg/mL, 48 h) 显著减少 HT29 细胞中 TUNEL 阳性凋亡细胞的数量，并抑制 Clostridium difficile toxin A 诱导的 caspase-3 激活 (凋亡的标志)[1]。
Periplanetasin-4 (100 μg/mL, 45 min) 完全抑制 HT29 细胞中由 Clostridium difficile toxin A 诱导的 ROS 产生增加[1]。
Periplanetasin-4 (100 μg/mL, 4 h) 显著阻断 HT29 细胞中 p38MAPK 的激活和 p21 的上调[1]。 Periplanetasin-4 (5 μM, 2-4 h) 在 Candida albicans ATCC 90028 细胞中显著增加 PI 流入和 DiBAC4(3) 积累[2]。
Periplanetasin-4 (5 μM, 2 h) 显著提高 Candida albicans ATCC 90028 细胞内 ROS 水平，增加线粒体超氧化物自由基和过氧化氢的产生[2]。
Periplanetasin-4 (5 μM, 2 h) 在 Candida albicans ATCC 90028 原生质体中显著诱导磷脂酰丝氨酸外化和半胱天冬酶激活[2]。
Periplanetasin-4 (5 μM, 2 h) 显著增加 Candida albicans ATCC 90028 细胞中丙二醛 (MDA) 水平，增强过氧化氢酶活性和总谷胱甘肽含量，导致线粒体膜电位崩溃，增加线粒体生物量，并促进线粒体碎片化[2]。
Periplanetasin-4 (5 μM, 2 h) 显著增加 Candida albicans ATCC 90028 细胞中 BCECF 和 C-DCFDA 荧光强度及线粒体钙水平，降低 DPH 荧光强度，并引发液泡功能障碍[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Periplanetasin-4 相关抗体:

Apoptosis Analysis[1]

Cell Line: Clostridium difficile toxin A induced HT29 cells
Concentration: 100 μg/mL
Incubation Time: 48 h
Result: Decreased the number of TUNEL-positive apoptotic HT29 cells.
Inhibited the activation of caspase-3.
体内研究
(In Vivo)

Periplanetasin-4 (100 μg/mL，小鼠回肠环内腔注射， 4 h) 显著改善小鼠肠道中毒素 A 诱导的黏膜损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Clostridium difficile toxin A-induced mouse enteritis model: 6-week-old mice were anesthetized by intraperitoneal injection of sodium pentobarbital (50 mg/kg)[1]
Dosage: 100 μg/mL co-administered with 3 nM Clostridium difficile toxin A
Administration: Intraluminal injection into mouse ileal loops for 4 h
Result: Ameliorated toxin A-induced mucosal damage in the mouse gut.
Reduced the elevation of interleukin-6 (IL-6) production in the ileal loop tissues of mice.
分子量

1503.81

Formula

C70H110N20O15S
CAS 号
Sequence

Leu-Arg-His-Lys-Val-Tyr-Gly-Tyr-Cys-Val-Leu-Gly-Pro-NH2
Sequence Shortening

LRHKVYGYCVLGP-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Periplanetasin-4 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Periplanetasin-42206807-06-7Periplanetasin4Periplanetasin 4Bacterialp38 MAPKReactive Oxygen Species (ROS)ApoptosisCaspasecolitisPeriplaneta Americanap38MAPKp21Clostridium difficile toxin AHT29 cellsInhibitorinhibitorinhibit

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