2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. PF-03049423

PF-03049423 (Compound PF-5) 是一种有效的，高选择性的 phosphodiesterase-5A 抑制剂，对大鼠和人血小板酶的 IC50 约为 0.2 nM。PF-03049423 可用于急性缺血性中风的研究。

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PF-03049423 Chemical Structure

PF-03049423 Chemical Structure

CAS No. : 402955-58-2

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Other Forms of PF-03049423:

PF-03049423 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PF-03049423 (Compound PF-5) is a potent and highly selective phosphodiesterase-5A inhibitor with an IC50 of about 0.2 nM for rat and human platelet enzyme. PF-03049423 can be used for the research of acute ischaemic stroke[1].

IC50 & Target[1]

PDE5A

 

rat and human platelet enzyme

~0.2 nM (IC50)

体内研究
(In Vivo)

PF-03049423 (Compound PF-5) (1-10 mg/kg; s.c.; b.i.d. for 7 days) promotes functional recovery in a rat model of severe stroke induced by permanent middle cerebral artery occlusion[1].
PF-03049423 (1.0 mg/kg b.i.d. or 0.6 mg/kg q.d. for 7 days) improves poststroke sensory–motor behavioral outcome even when the treatment is initiated 24-72 hours after occlusion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats, middle cerebral artery occlusion (MCA-o) model[1]
Dosage: 0.1, 1, or 10 mg/kg
Administration: Subcutaneous injection, b.i.d. for 7 days
Result: Improved functional recovery at 1 mg/kg and 10 mg/kg.
Clinical Trial
Formula

C24H32N6O4.xHCl
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PF-03049423 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-03049423402955-58-2PF03049423PF 03049423Phosphodiesterase (PDE)acute ischaemic strokemiddle cerebral artery occlusionMCA-oInhibitorinhibitorinhibit

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产品名称：
PF-03049423
目录号：
HY-10679A
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