1. Neuronal Signaling
  2. Cholinesterase (ChE)
  3. Piperilate

Piperilate  (Synonyms: Pipethanate)

目录号: HY-105790
产品使用指南

Piperilate (Pipethanate) 是希泽平衍生物 PAF 拮抗剂与抗胆碱能活性分子混合物的一种,可用于支气管哮喘研究。Piperilate 还能引起低血压,拯救被有机磷中毒的老鼠。

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Piperilate Chemical Structure

Piperilate Chemical Structure

CAS No. : 4546-39-8

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查看 Cholinesterase (ChE) 亚型特异性产品:

  • 生物活性

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生物活性

Piperilate (Pipethanate) is one of the mixtures of hetrazepine derivative PAF antagonists with anticholinergics, can be used for bronchial asthma research. Piperilate also causes hypotension and rescues mice poisoned by the organophosphates[1][2][3].

体内研究
(In Vivo)

Piperilate (11.3 mg/kg, 29.42 mg/kg; i.p.; single dose) shows anticholinergic activity, and (30 mg/kg; i.p.; single dose) exerts efficacy in mice poisoned by the organophosphates[1].
Piperilate (1 mg/kg; i.v.) causes hypotension in rabbit which is not blocked by dichloroisoproterenol or Atropine (HY-B1205)[2].
Piperilate (3 mg/kg; i.v.) decreases respiration and heart rate of test rabbits, blocks the Adrenaline (HY-122304)-induced constriction of an isolated rabbit auricle preparation[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male albino mice (18-22 g)[1]
Dosage: 11.3 mg/kg, 29.42 mg/kg
Administration: Intraperitoneal injection; single dose
Result: Showed anticholinergic activity with EC50 values of 11.33 mg/kg (antagonism of oxotremorine induced salivation) and 29.42 mg/kg (antagonism of oxotremorine induced tremor) in mice.
分子量

339.43

Formula

C21H25NO3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Piperilate 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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