2. Cell Cycle/DNA Damage Apoptosis
  3. Wee1 Apoptosis
  4. PKMYT1-IN-10

PKMYT1-IN-10 是一种选择性的 PKMYT1 抑制剂，其 IC50 为 3 nM。PKMYT1-IN-10 可抑制克隆形成，诱导细胞凋亡 (apoptosis)，并诱导癌细胞周期停滞于 S 期。PKMYT1-IN-10 具有良好的肝微粒体稳定性和血浆稳定性，且对 CYPs 的抑制作用极小。PKMYT1-IN-10 可用于卵巢癌和乳腺癌的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PKMYT1-IN-10

PKMYT1-IN-10 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

PKMYT1-IN-10 相关抗体

Top Publications Citing Use of Products

查看 Wee1 亚型特异性产品:

查看所有亚型
PKMYT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PKMYT1-IN-10 is a selective PKMYT1 inhibitor with an IC50 of 3 nM. PKMYT1-IN-10 inhibits colony formation, induces apoptosis, and induces S-phase cancer cell cycle arrest. PKMYT1-IN-10 exhibits liver microsomal stability, favorable plasma stability, minimal CYPs inhibition. PKMYT1-IN-10 can be used for the studies of ovarian cancer and breast cancer[1].

IC50 & Target[1]

PKMYT1

3 nM (IC50)

体外研究
(In Vitro)

PKMYT1-IN-10 (Compound A30) 表现出强效的细胞抑制活性，在 OVCAR3、HCC1569 和 A549 细胞系中的 IC50 值分别为 0.32 μM、0.33 μM 和 > 8 μM[1]。
PKMYT1-IN-10 (0.125-2 μM, 14 days) 可抑制 OVCAR3 和 HCC1569 细胞中的集落形成，EC50 分别为 0.37 和 0.35 μM[1]。
PKMYT1-IN-10 (0.3-2.4 μM, 5 days) 可诱导 HCC1569 细胞凋亡，并在 HCC1569 细胞和 OVCAR3 中诱导 S 期特异性细胞周期停滞[1]。
PKMYT1-IN-10 (37.5-600 nM) 与 Gemcitabine (HY-17026) 表现出高度协同作用，在 HCC1569 细胞和 OVCAR3 细胞中的联合指数 (CI) 值分别为 < 0.5 和 0.5-0.8[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PKMYT1-IN-10 相关抗体:

Apoptosis Analysis[1]

Cell Line: HCC1569 cells
Concentration: 0.3, 0.6 and 1.2 μM
Incubation Time: 5 days
Result: Reached the apoptosis rate by 54.7% at a concentration of 2.4 μM in HCC1569 cells.

Cell Cycle Analysis[1]

Cell Line: HCC1569 cells and OVCAR3 cells
Concentration: 0.3, 0.6 and 1.2 μM
Incubation Time: 5 days
Result: Increased the proportion of cells in the S phase, without causing the typical G2/M arrest.
药代动力学
(Parmacokinetics)[1]
Species Dose Route Indicator value
Mice 3 mg/kg i.v. T1/2 0.20 h
Mice 30 mg/kg p.o. T1/2 0.70 h
Mice 3 mg/kg i.v. Tmax 0.08 h
Mice 30 mg/kg p.o. Tmax 0.33 h
Mice 3 mg/kg i.v. Cmax 622 ng/mL
Mice 30 mg/kg p.o. Cmax 721 ng/mL
Mice 3 mg/kg i.v. AUC0-t 188 ng·h/mL
Mice 30 mg/kg p.o. AUC0-t 497 ng·h/mL
Mice 3 mg/kg i.v. AUC0-∞ 191 ng·h/mL
Mice 30 mg/kg p.o. AUC0-∞ 504 ng·h/mL
Mice 3 mg/kg i.v. MRT0-t 0.12 h
Mice 30 mg/kg p.o. MRT0-t 0.57 h
Mice 3 mg/kg i.v. MRT0-∞ 0.14 h
Mice 30 mg/kg p.o. MRT0-∞ 0.63 h
Mice 3 mg/kg i.v. Vz 4584 mL/kg
Mice 30 mg/kg p.o. F 26.44 %
Mice 3 mg/kg i.v. CL 263 mL/min/kg
分子量

453.51

Formula

C22H23N5O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PKMYT1-IN-10 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PKMYT1-IN-10Wee1Apoptosisovarian cancerbreast cancerapoptosisOVCAR3 cellsHCC1569 cellsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
PKMYT1-IN-10
目录号：
HY-175817
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z