2. Peptides
  3. Properdistatin

Properdistatin 是一种来源于备解素的血小板反应蛋白 1 (TSP-1) 结构域的肽。Properdistatin 抑制血管生成并改善血管功能。Properdistatin 具有用于黑色素瘤研究的潜力。

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Custom Peptide Synthesis

Properdistatin Chemical Structure

Properdistatin Chemical Structure

CAS No. : 945373-85-3

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Properdistatin 相关抗体

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  • 生物活性

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生物活性

Properdistatin is a peptide derived from the thrombospondin 1 (TSP-1) domain of properdin. Properdistatin inhibits angiogenesis and improves vascular function. Properdistatin has the potential for the research of melanoma[1].

体内研究
(In Vivo)

Properdistatin (80 mg/kg; 腹腔注射; 每日一次, 持续 4 天) 抑制小鼠黑色素瘤异种移植模型的血管生成并改善血管功能[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult female BALB/c nu/nu mice (R-18, A-07, and D-12 human melanoma cells)[1]
Dosage: 80 mg/kg
Administration: I.p.; daily for 4 days
Result: Inhibited angiogenesis in human melanoma xenografts with low TSP-1 expression, selectively removed small-diameter capillaries, but did not change the morphology of tumor arterioles or tumor venules, and reduced blood supply times and increased plasma velocities.
分子量

2177.47

Formula

C89H149N33O27S2
CAS 号
Sequence Shortening

GPWEPCSVTCSKGTRTRRR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

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  • Do most proteins show cross-species activity?

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Keywords:

Properdistatin945373-85-3OthersangiogenesisTSP-1melanomaR-18A-07D-12 cellsInhibitorinhibitorinhibit

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