1. 重组蛋白
  2. Ubiquitin Related Proteins
  3. Ubiquitin Enzymes
  4. E1 Enzymes

E1 Enzymes  (泛素激活酶)

Ubiquitin or ubiquitin-like proteins (UBLs) carboxyl termini are attached to other proteins, or in some cases lipids, generally through E1-E2-E3 multienzyme cascades. The E1 activating enzymes (ubiquitin-activating enzyme) serve to activate ubiquitin/UBLs through C-terminal adenylation and thiol transfer and to coordinate the utilization of ubiquitin/UBLs in specific downstream pathways by charging cognate E2 enzymes, which then interact with the downstream ubiquitylation machinery to coordinate modification of the target.  In humans, there are eight E1 activating enzymes are known so far, including canonical (UBA1, UBA6, UBA7, SAE, and NAE) and non-canonical (UBA4, UBA5, and ATG7) E1 enzymes.

目录号 产品名 / 同用名 种属 表达系统
  • HY-P74485
    UBA1 Protein, Human (sf9, His-GST)

    Ubiquitin-like modifier-activating enzyme 1; Protein A1S9; UBA1; A1S9T; UBE1

    Human Sf9 insect cells
    UBA1 蛋白启动泛素结合,标记蛋白质在泛素-蛋白酶体系统中降解。UBA1 Protein, Human (sf9, His-GST) 是重组的 UBA1 蛋白,由 Sf9 insect cells 表达,带有 N-His, N-GST 标签。UBA1 Protein, Human (sf9, His-GST) 全长 1057 个氨基酸,分子量约为 ~130 kDa。
  • HY-P71395
    UBA5 Protein, Human (His)

    Ubiquitin-like modifier-activating enzyme 5; ThiFP1; UFM1-activating enzyme; Ubiquitin-activating enzyme E1 domain-containing protein 1; UBE1DC1; UBA5

    Human E. coli
    UBA5 蛋白在 ufmylation 中激活 UFM1,将 UFM1 的 C 端甘氨酸残基与 E1 中的半胱氨酸残基连接起来。UBA5 Protein, Human (His) 是重组的 UBA5 蛋白,由 E. coli 表达,带有 N-6*His 标签。UBA5 Protein, Human (His) 全长 404 个氨基酸,分子量分别为 14 & 40-60 kDa。
  • HY-P71567
    OGDC-E Protein, Mouse (His-SUMO)

    Ogdh; Kiaa4192; 2-oxoglutarate dehydrogenase; mitochondrial; EC 1.2.4.2; 2-oxoglutarate dehydrogenase complex component E1; OGDC-E1; Alpha-ketoglutarate dehydrogenase

    Mouse E. coli
    OGDC-E 蛋白是 2-酮戊二酸脱氢酶复合物的重要组成部分,可驱动线粒体中 2-酮戊二酸转化为琥珀酰辅酶A,这是克雷布斯循环中的关键步骤。它利用二磷酸硫胺素进行脱羧,连接到 E2 酶并参与 KAT2A 的核组蛋白琥珀酰化。OGDC-E Protein, Mouse (His-SUMO) 是重组的 OGDC-E 蛋白,由 E. coli 表达,带有 N-SUMO, N-6*His 标签。OGDC-E Protein, Mouse (His-SUMO) 全长 329 个氨基酸,分子量约为 ~54 kDa。
  • HY-P71643
    SAE1 Protein, Human (GST)

    Activator of SUMO1; AOS1; HSPC140; Sae1; SAE1_HUMAN; Sentrin/SUMO activating protein AOS1; UBL E1A; UBLE1A

    Human E. coli
    SAE1 蛋白形成异二聚体,充当 SUMO1、SUMO2、SUMO3 和潜在的 SUMO4 的 E1 连接酶。它关键介导 SUMO 蛋白的 ATP 依赖性激活,从而能够与 UBA2/SAE2 的活性位点半胱氨酸形成硫酯键。这个过程对于通过苏酰化修饰蛋白质至关重要。SAE1 Protein, Human (GST) 是重组的 SAE1 蛋白,由 E. coli 表达,带有 N-GST 标签。SAE1 Protein, Human (GST) 全长 346 个氨基酸,分子量约为 ~65.4 kDa。
目录号 产品名 作用方式 纯度