1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR
  3. PS372424

PS372424 

目录号: HY-111149
产品使用指南

PS372424,CXCL10 的三个氨基酸片段,是一种特异的人 CXCR3 激动剂,具有抗炎活性,它抑制 CXCR3 配体 CXCL10 与 CXCR3 受体的结合,IC50 值为 42 nM。

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PS372424 Chemical Structure

PS372424 Chemical Structure

CAS No. : 914291-61-5

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Description

PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity, which inhibits the binding of CXCR3 ligand CXCL10 to CXCR3 receptor with IC50 of 42 nM[1][2][3].

IC50 & Target[1]

CXCR3

 

In Vitro

PS372424 (10-200 nM; 30 min) causes a concentration-dependent phosphorylation of CCR5 on CXCR3+ T cells not in CXCR3- T cells[1].

Western Blot Analysis[1]

Cell Line: CXCR3+ T cells and CXCR3- T cells
Concentration: 10, 50, 100, or 200 nM
Incubation Time: 30 minutes
Result: Caused a concentration-dependent phosphorylation of CCR5 on CXCR3+ T cells. Did not result in phosphorylation of CCR5 on CXCR3- T cells.
Molecular Weight

588.74

Formula

C₃₃H₄₄N₆O₄

CAS No.

914291-61-5

SMILES

O=C([C@H]1N(C(CCC(C2=CC=CC=C2)=O)=O)CC3=C(C=CC=C3)C1)N[C@H](C(NCC4CCCCC4)=O)CCCNC(N)=N

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
PS372424
目录号:
HY-111149
需求量:

PS372424

Cat. No.: HY-111149