2. Apoptosis
  3. Apoptosis
  4. QEQLERALNSS TFA

QEQLERALNSS TFA 是一种由促红细胞生成素衍生的螺旋 B 表面肽 (HBSP)，具有组织保护活性。 QEQLERALNSS TFA 保护心肌细胞凋亡 (apoptosis)。

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Custom Peptide Synthesis

QEQLERALNSS TFA Chemical Structure

QEQLERALNSS TFA Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

QEQLERALNSS TFA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

QEQLERALNSS TFA is a helix B surface peptide (HBSP) derived from erythropoietin with tissue protective activities. QEQLERALNSS TFA protects cardiomyocytes from apoptosis[1].

体外研究
(In Vitro)

QEQLERALNSS (2.5 and 25 ng/mL; 12 h) clearly decreases TNF-α-induced apoptosis of cardiomyocytes[1].
QEQLERALNSS (2.5 ng/mL; 5 min) activates critical signaling pathways of cell survival, including Akt, ERK1/2, and STAT3 in cardiomyocytes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

QEQLERALNSS TFA 相关抗体:

Apoptosis Analysis[1]

Cell Line: Cardiomyocytes
Concentration: 2.5 and 25 ng/mL
Incubation Time: 12 h
Result: Decreased the number of apoptotic cells (≈80% pretreatment, ≈60% without pretreatment) induced by TNF-α (50 pg/mL).

Western Blot Analysis[1]

Cell Line: Cardiomyocytes
Concentration: 2.5 ng/mL
Incubation Time: 5 min
Result: Rapidly activated Akt, ERK1/2, and STAT3 with a peak at 1 min after incubation.
体内研究
(In Vivo)

QEQLERALNSS (8 nmol/kg; i.p.; daily for 2 weeks) shows protective effects on ischemia reperfusion and Cyclosporin A (HY-B0579) induced renal injury in rats[2].
QEQLERALNSS (30 μg/kg; s.c.; three times a week for 6 month) results in a significant decrease in the number of apoptotic cardiomyocytes in the cardiac sections compared with the control in DCM hamsters[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats, renal IR injury model[2]
Dosage: 8 nmol/kg
Administration: Intraperitoneal injection, once a day for 2 weeks
Result: Decreased the level of blood urea nitrogen and tubulointerstitial damage induced by Cyclosporin A (HY-B0579). Reduced apoptotic cells, myeloperoxidase (MPO)+ cells and active caspase-3+ cells.
分子量

1388.36

Formula

C53H88F3N17O23
Sequence Shortening

QEQLERALNSS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

QEQLERALNSS TFA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

QEQLERALNSSApoptosisIschemia reperfusioncyclosporine Amyocardial infarctionheart failureInhibitorinhibitorinhibit

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目录号：
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