2. Neuronal Signaling Apoptosis
  3. Amyloid-β MDM-2/p53 Apoptosis
  4. Quinovic acid

Quinovic acid 是一种三萜类化合物。Quinovic acid 可通过上调 Nrf2/HO-1 通路抑制氧化应激，从而改善 β-淀粉样蛋白 (Amyloid-β) 负荷、p53 表达及胆固醇蓄积。Quinovic acid 可通过上调死亡受体 5 (DR5) 诱导癌细胞凋亡 (apoptosis)。Quinovic acid 可用于癌症、炎症、代谢性疾病和神经系统疾病的研究，如肺癌和阿尔茨海默病 (AD)。

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Quinovic acid

Quinovic acid Chemical Structure

CAS No. : 465-74-7

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1 mg ￥3430
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Quinovic acid 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Quinovic acid is triterpene. Quinovic acid can ameliorate the Amyloid-β burden, p53 expression and cholesterol accumulation by deterring the oxidative stress through upregulating the Nrf2/HO-1 pathway. Quinovic acid can induce cancer cells apoptosis by upregulating death receptor 5 (DR5). Quinovic acid can be used for the researches of cancer, inflammation, metabolic and neurological disease, such as lung cancer and Alzheimer’s disease (AD)[1][2].

体外研究
(In Vitro)

Quinovic acid (5-115 μM, 24 h) 具有低细胞毒性，并能减轻寡聚 Aβ (AβO) 诱导的 SH-SY5Y 细胞死亡[1]。
Quinovic acid (85 μM, 24 h) 可下调 AβO 诱导的 SH-SY5Y 细胞中 p53 和 3-羟基-3-甲基戊二酰辅酶 A 还原酶 (HMGCR) 的表达[1]。
Quinovic acid (QA) (5-40 μM, 24-72 h) 可抑制 A549、H1299、MCF-7 和 MDA-MB-231 细胞的增殖和活力[2]。
Quinovic acid (QA) (25-35 μM, 24 h) 可诱导 MDA-MB-231 和 A549 细胞凋亡[2]。
Quinovic acid (25 μM, 4-24 h) 可上调 A549、MCF-7 和 MDA-MB-231 细胞中死亡受体 5 (DR5) 的 mRNA 和蛋白水平[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Quinovic acid 相关抗体:

Western Blot Analysis[1]

Cell Line: MDA-MB-231 and A549 cells
Concentration: 25, 30 and 35 μM
Incubation Time: 24 h
Result: Reduced procaspase 3 and 8 levels.
Increased cleaved PARP levels.
体内研究
(In Vivo)

Quinovic acid (50 mg/kg，腹腔注射，每隔一天一次，持续 3 周) 能显著改善 Aβ(1-42) 诱导的 C57BL/6J 小鼠的病理损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice treated with Aβ(1-42)[1]
Dosage: 50 mg/kg
Administration: Intraperitoneally injection, every other day for 3 weeks
Result: Reduced Aβ oligomers, monomers, and BACE1 expression in cortex/hippocampus and decreased Aβ burden.
Downregulated p53 and HMGCR expressions and reduced total and free cholesterol levels.
Activated the Nrf2/HO-1 pathway, reduced ROS levels and restored GSH/GSSG ratio.
Downregulated GFAP, Iba-1, p-NF-κB, and IL-1β.
Downregulated Bax, cytochrome c, cleaved caspase-3; upregulates Bcl-2 and upregulated PSD-95 and synaptophysin.
Enhanced cognitive ability.
分子量

486.68

Formula

C30H46O5
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: 96.0%

COA (290 KB)

产品使用指南 (1538 KB)
参考文献

Quinovic acid 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quinovic acid465-74-7Amyloid-βMDM-2/p53Apoptosisβ-amyloid peptideAβAbetaTriterpenep53CholesterolOxidative stressNrf2/HO-1DR5Lung cancerBreast cancerAlzheimer’s diseaseA549H1299MCF-7MDA-MB-231Inhibitorinhibitorinhibit

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