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  5. CSF1R 蛋白, Mouse (HEK293, His)

CSF1R 蛋白, Mouse (HEK293, His)

目录号: HY-P72952
COA 产品使用指南

CSF1R蛋白是CSF1和IL34的酪氨酸蛋白激酶受体,在造血细胞,特别是单核吞噬细胞中发挥关键的调节作用。它的影响涵盖先天免疫、炎症、破骨细胞功能、骨骼发育和生育能力。CSF1R 蛋白, Mouse (HEK293, His) 是重组的 CSF1R 蛋白,由 HEK293 表达,带有 C-His 标签。CSF1R 蛋白, Mouse (HEK293, His) 全长 492 个氨基酸,糖基化后的分子量为 ~80-90 kDa。

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描述

The CSF1R protein is a tyrosine protein kinase receptor for CSF1 and IL34 and plays a critical regulatory role in hematopoietic cells, especially mononuclear phagocytes. Its effects span innate immunity, inflammation, osteoclast function, skeletal development, and fertility. CSF1R Protein, Mouse (HEK293, His) is the recombinant mouse-derived CSF1R protein, expressed by HEK293 , with C-His labeled tag. The total length of CSF1R Protein, Mouse (HEK293, His) is 492 a.a., with molecular weight (glycosylation form) of ~80-90 kDa.

研究背景

CSF1R 蛋白是一种酪氨酸蛋白激酶,作为 CSF1 和 IL34 的细胞表面受体,对造血前体细胞(尤其是巨噬细胞和单核细胞等单核吞噬细胞)的生存、增殖和分化发挥关键控制作用。它在先天免疫和炎症过程中的作用通过其响应 IL34 和 CSF1 促进促炎趋化因子的释放而得到强调。此外,CSF1R在破骨细胞增殖和分化、骨吸收的调节中发挥着关键作用,是正常骨骼和牙齿发育所不可缺少的。它对于男性和女性的正常生育能力以及怀孕期间乳腺中乳管和腺泡结构的发育至关重要。值得注意的是,CSF1R 影响肌动蛋白细胞骨架的重组,调节膜皱褶的形成、细胞粘附、细胞迁移,并促进癌细胞侵袭。配体结合后,CSF1R 激活多种信号通路,包括 ERK1/2、JNK、PI3K/AKT、MAP 激酶(MAPK1/ERK2 和/或 MAPK3/ERK1)和 SRC 家族激酶(SRC、FYN、YES1)。其下游效应涉及多种靶蛋白的磷酸化,例如 PIK3R1、PLCG2、GRB2、SLA2 和 CBL。此外,CSF1R 介导 STAT 家族成员(STAT3、STAT5A 和/或 STAT5B)的激活,并促进 SHC1 和 INPP5D/SHIP-1 的酪氨酸磷酸化。受体信号传导受到蛋白磷酸酶(包括 INPP5D/SHIP-1)以及激活受体的快速内化的严格调节。在中枢神经系统中,CSF1R 可能有助于小胶质细胞巨噬细胞的发育。

生物活性

Measured by its ability to inhibit the M-CSF-induced proliferation of M-NFS-60 mouse myelogenous leukemia lymphoblast cells. The ED50 for this effect is 0.4080 µg/mL in the presence of 10 ng/mL mouse M-CSF. Corresponding to a specific activity is 2.451×103 units/mg.

  • Measured by its ability to inhibit the M-CSF-induced proliferation of M-NFS-60 mouse myelogenous leukemia lymphoblast cells. The ED50 for this effect is 0.4080 µg/mL in the presence of 10 ng/mL mouse M-CSF, corresponding to a specific activity is 2.451×103 units/mg.
种属

Mouse

表达系统

HEK293

标签

C-His

蛋白编号

P09581 (A20-S511)

基因 ID
蛋白结构
N-term
CSF1R (A20-S511)
Accession # P09581
His
C-term
中文名
重组鼠CSF1R蛋白
同用名
Macrophage colony-stimulating factor 1 receptor; CSF-1R; M-CSF-R; CD115; CSF1R; FMS
氨基酸序列

APVIEPSGPELVVEPGETVTLRCVSNGSVEWDGPISPYWTLDPESPGSTLTTRNATFKNTGTYRCTELEDPMAGSTTIHLYVKDPAHSWNLLAQEVTVVEGQEAVLPCLITDPALKDSVSLMREGGRQVLRKTVYFFSPWRGFIIRKAKVLDSNTYVCKTMVNGRESTSTGIWLKVNRVHPEPPQIKLEPSKLVRIRGEAAQIVCSATNAEVGFNVILKRGDTKLEIPLNSDFQDNYYKKVRALSLNAVDFQDAGIYSCVASNDVGTRTATMNFQVVESAYLNLTSEQSLLQEVSVGDSLILTVHADAYPSIQHYNWTYLGPFFEDQRKLEFITQRAIYRYTFKLFLNRVKASEAGQYFLMAQNKAGWNNLTFELTLRYPPEVSVTWMPVNGSDVLFCDVSGYPQPSVTWMECRGHTDRCDEAQALQVWNDTHPEVLSQKPFDKVIIQSQLPIGTLKHNMTYFCKTHNSVGNSSQYFRAVSLGQSKQLPDES

分子量

Approximately 80-90 kDa, due to glycosylation.

纯度
  • Greater than 95% as determined by reducing SDS-PAGE.
性状

无菌粉末

组分

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料

CSF1R Protein, Mouse (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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