2. 重组蛋白
  3. Cytokines and Growth Factors Receptor Proteins Enzymes & Regulators
  4. FGF Family Receptor Tyrosine Kinases Protein Tyrosine Kinases
  5. FGFR

FGFR  (FGFR 家族)

重组蛋白定制服务

成纤维细胞生长因子受体 (FGFRs) 是表达在细胞膜上的受体酪氨酸激酶成员，参与多种生物过程，包括细胞生长、迁移、分化、生存和凋亡，对胚胎和神经发育、骨骼和器官形成至关重要。以及成人组织的稳态。顾名思义，FGFRs 结合成纤维细胞生长因子家族的成员蛋白，介导信号转导。FGFRs 由具有三个不同的免疫球蛋白样亚结构域 (D1、D2和D3) 的 N 端细胞外结构域、一个跨膜结构域和一个胞浆酪氨酸激酶结构域组成。在人类中，目前鉴定出 6 个FGFR家族成员 (FGFR1-6)。其中，FGFR5 (也称为 “FGFRL1”) 是一种截短的无细胞内激酶结构域的FGFR, 它在调节 FGF-FGFR1 信号通路的过度激活中发挥作用。 配体的结合引发 FGFRs 的二聚和激活，激活四个关键的下游信号通路：RAS-RAF-MAPK, PI3K-AKT, STAT和PLCγ。FGF/FGFR信号参与几乎所有器官的发育，如肺、心脏、泌尿系统、大脑、骨骼、肌肉和皮肤/附器，以及血管生成和淋巴管生成。FGF/ FGFR 信号轴功能异常可在多种人类疾病中观察到，如先天性颅缝早闭和侏儒综合征，以及慢性肾病 (CKD)、肥胖、胰岛素抵抗和各种肿瘤。

Fibroblast growth factor receptors (FGFRs) are receptor tyrosine kinase members expressed on the cell membrane that are involved in a variety of biological processes, including cell growth, migration, differentiation, survival, and apoptosis, and are essential for embryonic and neural development, skeletal and organ formation, and adult tissue homoeostasis. As their name implies, FGFRs bind to members of the fibroblast growth factor family of proteins, mediating signal transduction. FGFRs are made of N-terminal extracellular domains with three different immunoglobulin-like subdomains (D1, D2 and D3), a transmembrane domain and a cytoplasmic tyrosine kinase domain. In humans, six FGFR family members are currently identified (FGFR1-6). Among them, FGFR5 (also known as “FGFRL1”) is a truncated FGFR without intracellular kinase domain and plays a role in regulating excessive activation of the FGF-FGFR1 signaling pathway. Binding of ligand triggers functional dimerization and transphosphorylation of FGFRs, activation of four key downstream signalling pathways: RAS-RAF-MAPK, PI3K-AKT, STAT and PLCγ. FGF/FGFR signaling participates in the development of almost all organs such as lung, heart, urinary system, brain, skeleton, muscle, and skin/appendage, as well as angiogenesis and lymphangiogenesis. The malfunction of FGF/FGFR signaling axis is observed in a variety of human diseases, such as congenital craniosynostosis and dwarfism syndromes, as well as chronic kidney disease (CKD), obesity, insulin resistance, and various tumors.

 
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