2. 重组蛋白
  3. Cytokines and Growth Factors CD Antigens Receptor Proteins Enzymes & Regulators
  4. FGF Family Stem Cell CD Proteins Epithelial cell CD Proteins Receptor Tyrosine Kinases Protein Tyrosine Kinases
  5. FGFR-2/CD332 FGFR
  6. FGFR-2
  7. FGFR-2 蛋白, Mouse (HEK293, Fc)

FGFR-2 蛋白, Mouse (HEK293, Fc)

目录号: HY-P76339
产品使用指南

FGFR2 也被称为 CD332 (分化簇332)，是成纤维细胞生长因子的受体。FGFR2 参与 RAS、MAPK1/ERK2、MAPK3/ERK1、MAP 激酶信号通路和 AKT1 信号通路的激活。FGFR2 通过 JAK2/STAT3 信号上调 PAI-1，诱导结直肠癌巨噬细胞 M2 极化。FGFR-2 蛋白, Mouse (HEK293, Fc) 是重组的 FGFR-2 蛋白，由 HEK293 表达，带有 C-hFc 标签。FGFR-2 蛋白, Mouse (HEK293, Fc) 全长 242 个氨基酸，分子量约为 ~89.9 KDa。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 μg   询价  
100 μg   询价  

* Please select Quantity before adding items.

Top Publications Citing Use of Products

  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

FGFR2, also known as CD332 (differentiated cluster 332), is a receptor for fibroblast growth factor. FGFR2 is involved in activation of RAS, MAPK1/ERK2, MAPK3/ERK1, MAP kinase signaling pathways, and AKT1 signaling pathways. FGFR2 up-regulates PAI-1 via JAK2/STAT3 signaling and induces M2 polarization in colorectal cancer macrophages. FGFR-2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived FGFR-2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of FGFR-2 Protein, Mouse (HEK293, Fc) is 242 a.a., with molecular weight of ~89.9 KDa.
研究背景

FGFR2 也被称为 CD332 (分化簇332)，是成纤维细胞生长因子的受体。FGFR2 在胚胎发育和组织修复，特别是骨和血管中具有重要作用。在促进角质形成细胞和未成熟成骨细胞增殖的同时，促进分化成骨细胞的凋亡。配体结合后，FGFR-2 α IIIc 激活多个信号级联反应，包括 PLCG1、FRS2 和 PAK4 的磷酸化。PLCG1 的激活触发细胞信号分子的产生，如二酰基甘油和肌醇1,4,5-三磷酸。FRS2的磷酸化导致 GRB2、GAB1、PIK3R1 和 SOS1 的募集，介导 RAS、MAPK1/ERK2、MAPK3/ERK1、MAP 激酶信号通路和 AKT1 信号通路的激活。FGFR2 通过 JAK2/STAT3 信号上调 PAI-1，诱导结直肠癌巨噬细胞 M2 极化。
种属

Mouse
表达系统

HEK293
标签

C-hFc
蛋白编号

E9Q5C3 (R22-E263)
基因 ID
蛋白结构
N-term
FGFR-2 (R22-E263)
Accession # E9Q5C3
hFc
C-term
同用名
Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK
分子量

Approximately 89.9 kDa.
纯度

Greater than 95% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

FGFR-2 Protein, Mouse (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
FGFR-2 Protein, Mouse (HEK293, Fc)
目录号：
HY-P76339
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z