1. Gene
  2. Fgfr2 - fibroblast growth factor receptor 2 Gene

Fgfr2 - fibroblast growth factor receptor 2 Gene

中文名称:成纤维细胞生长因子受体 2

种属: Mus musculus

同用名: Bek; svs; KGFR; Fgfr7; Fgfr-2; Fgfr-7; Fgfr2b; KGFRTr

基因 ID: 14183 | 基因类型: protein coding

关于 Fgfr2

Chromosome 7: 129,764,181-132,725,079 reverse strand.GRCm39:CM001000.3

This gene has 27 transcripts (splice variants), 219 orthologues, 53 paralogues and is associated with 278 phenotypes. Ubiquitous expression in limb E14.5 (RPKM 15.2), lung adult (RPKM 13.2) and 25 other tissues.

功能概要

该基因编码的蛋白可启动成纤维细胞生长因子结合活性。参与成纤维细胞生长因子受体信号通路;神经元的前脑生成;和细胞周期的正向调节。作用于多个过程的上游或内部,包括动物器官发育;细胞群增殖的正向调节;和信号转导的调节。位于兴奋性突触和细胞核。以多种结构表达,包括消化系统;脑;泌尿生殖系统;肢;和感觉器官。用于研究Beare-Stevenson cutis gyrata综合征;克鲁宗综合症;菲佛综合症;尖头并指畸形;和肠闭锁。该基因的人类直系同源基因与多种疾病有关,包括 Beare-Stevenson 皮肤回旋综合症; Jackson-Weiss 综合症; LADD 综合症;生殖器官癌(多发性);和缝合早闭(多个)。与人 FGFR2(成纤维细胞生长因子受体 2)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables Fibroblast Growth Factor binding activity. Involved in Fibroblast Growth Factor receptor signaling pathway; forebrain generation of neurons; and positive regulation of cell cycle. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and regulation of signal transduction. Located in excitatory synapse and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Used to study Beare-Stevenson cutis gyrata syndrome; Crouzon syndrome; Pfeiffer syndrome; acrocephalosyndactylia; and intestinal atresia. Human ortholog(s) of this gene implicated in several diseases, including Beare-Stevenson cutis gyrata syndrome; Jackson-Weiss syndrome; LADD syndrome; reproductive organ Cancer (multiple); and synostosis (multiple). Orthologous to human FGFR2 (Fibroblast Growth Factor receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Fgfr2 基因产物(3)

mRNA Protein Name
NM_010207.2 NP_034337.2 fibroblast growth factor receptor 2 isoform IIIc
NM_201601.2 NP_963895.2 fibroblast growth factor receptor 2 isoform IIIb
NM_001347638.1 NP_001334567.1 fibroblast growth factor receptor 2 isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables fibroblast growth factor binding IDA
IDA: 通过直接分析推断
9435295 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
8393815 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of ERK1 and ERK2 cascade IGI
IGI: 通过遗传相互作用推断
17202188 MGI
acts upstream of or within angiogenesis IGI
IGI: 通过遗传相互作用推断
16778080 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: 通过突变表型推断
12666202 MGI
acts upstream of or within axonogenesis IMP
IMP: 通过突变表型推断
17951031 MGI
acts upstream of or within bone development IMP
IMP: 通过突变表型推断
16989802 MGI
acts upstream of or within bone mineralization IMP
IMP: 通过突变表型推断
12756187 MGI
acts upstream of or within bone morphogenesis IMP
IMP: 通过突变表型推断
10518547 MGI
acts upstream of or within branch elongation involved in salivary gland morphogenesis IGI
IGI: 通过遗传相互作用推断
15972105 MGI
acts upstream of or within branch elongation involved in salivary gland morphogenesis IMP
IMP: 通过突变表型推断
15972105 MGI
acts upstream of or within branching involved in labyrinthine layer morphogenesis IMP
IMP: 通过突变表型推断
9435295 MGI
acts upstream of or within branching involved in prostate gland morphogenesis IMP
IMP: 通过突变表型推断
12666202 MGI
acts upstream of or within branching involved in salivary gland morphogenesis IMP
IMP: 通过突变表型推断
11731698 MGI
acts upstream of or within branching morphogenesis of a nerve IMP
IMP: 通过突变表型推断
17951031 MGI
acts upstream of or within bud elongation involved in lung branching IMP
IMP: 通过突变表型推断
16989802 MGI
acts upstream of canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
18533146 MGI
acts upstream of cardiac muscle cell proliferation IGI
IGI: 通过遗传相互作用推断
15621532 MGI
acts upstream of cell division IMP
IMP: 通过突变表型推断
14530295 MGI
acts upstream of or within cell fate commitment IDA
IDA: 通过直接分析推断
15509736 MGI
acts upstream of or within cell fate commitment IMP
IMP: 通过突变表型推断
16989802 MGI
acts upstream of cell population proliferation IGI
IGI: 通过遗传相互作用推断
16778080 MGI
acts upstream of cell population proliferation IMP
IMP: 通过突变表型推断
14530295 MGI
acts upstream of or within cell-cell signaling IMP
IMP: 通过突变表型推断
15199404 MGI
acts upstream of or within coronal suture morphogenesis IMP
IMP: 通过突变表型推断
19389359 MGI
acts upstream of or within digestive tract development IMP
IMP: 通过突变表型推断
15234214 MGI
acts upstream of or within embryonic digestive tract morphogenesis IMP
IMP: 通过突变表型推断
16618415 MGI
acts upstream of or within embryonic organ development IMP
IMP: 通过突变表型推断
9435295 MGI
acts upstream of or within embryonic organ morphogenesis IMP
IMP: 通过突变表型推断
15843416 MGI
acts upstream of or within embryonic pattern specification IMP
IMP: 通过突变表型推断
16618415 MGI
acts upstream of or within endodermal digestive tract morphogenesis IMP
IMP: 通过突变表型推断
21550054 MGI
acts upstream of or within epidermis morphogenesis IMP
IMP: 通过突变表型推断
14530295 MGI
acts upstream of or within epithelial cell differentiation IMP
IMP: 通过突变表型推断
16618415 MGI
acts upstream of epithelial cell proliferation IGI
IGI: 通过遗传相互作用推断
15972105 MGI
acts upstream of epithelial cell proliferation IMP
IMP: 通过突变表型推断
15199404 MGI
acts upstream of or within epithelial cell proliferation involved in salivary gland morphogenesis IGI
IGI: 通过遗传相互作用推断
15972105 MGI
acts upstream of or within epithelial cell proliferation involved in salivary gland morphogenesis IMP
IMP: 通过突变表型推断
15972105 MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis IMP
IMP: 通过突变表型推断
24058167 MGI
acts upstream of or within fibroblast growth factor receptor apoptotic signaling pathway IMP
IMP: 通过突变表型推断
16720875 MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
15621532 MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
9435295 MGI
involved in fibroblast growth factor receptor signaling pathway involved in hemopoiesis IMP
IMP: 通过突变表型推断
20345253 MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway involved in mammary gland specification IMP
IMP: 通过突变表型推断
16720875 MGI
involved in fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell IMP
IMP: 通过突变表型推断
20345253 MGI
involved in fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development IMP
IMP: 通过突变表型推断
20410112 MGI
involved in fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow IMP
IMP: 通过突变表型推断
20345253 MGI
acts upstream of or within gland morphogenesis IMP
IMP: 通过突变表型推断
17202188 MGI
acts upstream of or within hair follicle morphogenesis IMP
IMP: 通过突变表型推断
14530295 MGI
acts upstream of or within in utero embryonic development IGI
IGI: 通过遗传相互作用推断
17687036 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
9435295 MGI
acts upstream of or within inner ear morphogenesis IMP
IMP: 通过突变表型推断
10934262 MGI
acts upstream of or within lacrimal gland development IMP
IMP: 通过突变表型推断
10821755 MGI
acts upstream of or within lateral sprouting from an epithelium IMP
IMP: 通过突变表型推断
12666202 MGI
acts upstream of or within lens fiber cell development IGI
IGI: 通过遗传相互作用推断
18455718 MGI
acts upstream of or within lens fiber cell development IMP
IMP: 通过突变表型推断
23136392 MGI
acts upstream of or within limb bud formation IMP
IMP: 通过突变表型推断
9435295 MGI
acts upstream of or within lung alveolus development IGI
IGI: 通过遗传相互作用推断
16989802 MGI
acts upstream of or within lung alveolus development IMP
IMP: 通过突变表型推断
16989802 MGI
acts upstream of or within lung development IGI
IGI: 通过遗传相互作用推断
16540513 MGI
acts upstream of or within lung development IMP
IMP: 通过突变表型推断
10518547 MGI
acts upstream of or within lung lobe morphogenesis IMP
IMP: 通过突变表型推断
16989802 MGI
acts upstream of or within lung-associated mesenchyme development IGI
IGI: 通过遗传相互作用推断
18533146 MGI
acts upstream of or within lung-associated mesenchyme development IMP
IMP: 通过突变表型推断
16989802 MGI
acts upstream of or within mammary gland bud formation IMP
IMP: 通过突变表型推断
11782400 MGI
acts upstream of or within membranous septum morphogenesis IMP
IMP: 通过突变表型推断
16687131 MGI
acts upstream of or within mesenchymal cell differentiation IGI
IGI: 通过遗传相互作用推断
16442091 MGI
acts upstream of or within mesenchymal cell differentiation involved in lung development IGI
IGI: 通过遗传相互作用推断
16989802 MGI
acts upstream of mesenchymal cell proliferation IGI
IGI: 通过遗传相互作用推断
16540513 MGI
acts upstream of or within mesenchymal cell proliferation involved in lung development IMP
IMP: 通过突变表型推断
16989802 MGI
acts upstream of or within midbrain development IGI
IGI: 通过遗传相互作用推断
17687036 MGI
acts upstream of mitotic nuclear division IGI
IGI: 通过遗传相互作用推断
18455718 MGI
acts upstream of or within morphogenesis of embryonic epithelium IMP
IMP: 通过突变表型推断
15843416 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IGI
IGI: 通过遗传相互作用推断
18455718 MGI
acts upstream of or within negative regulation of mitotic nuclear division IGI
IGI: 通过遗传相互作用推断
18455718 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
16989802 MGI
acts upstream of or within neuromuscular junction development IMP
IMP: 通过突变表型推断
17418794 MGI
acts upstream of or within odontogenesis IMP
IMP: 通过突变表型推断
17951031 MGI
involved in orbitofrontal cortex development IMP
IMP: 通过突变表型推断
20410112 MGI
acts upstream of or within organ growth IMP
IMP: 通过突变表型推断
16618415 MGI
acts upstream of or within otic vesicle formation IMP
IMP: 通过突变表型推断
9435295 MGI
acts upstream of or within outflow tract septum morphogenesis IMP
IMP: 通过突变表型推断
16687131 MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IGI
IGI: 通过遗传相互作用推断
17202188 MGI
acts upstream of or within positive regulation of Wnt signaling pathway IMP
IMP: 通过突变表型推断
16989802 MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
18533146 MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
16720875 MGI
acts upstream of or within positive regulation of cardiac muscle cell proliferation IGI
IGI: 通过遗传相互作用推断
15621532 MGI
involved in positive regulation of cell cycle IMP
IMP: 通过突变表型推断
20410112 MGI
acts upstream of or within positive regulation of cell division IMP
IMP: 通过突变表型推断
14530295 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
18187602 MGI
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
20410112 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IGI
IGI: 通过遗传相互作用推断
15972105 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IMP
IMP: 通过突变表型推断
15199404 MGI
acts upstream of or within positive regulation of epithelial cell proliferation involved in lung morphogenesis IMP
IMP: 通过突变表型推断
16989802 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: 通过突变表型推断
21492869 MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation IGI
IGI: 通过遗传相互作用推断
16540513 MGI
acts upstream of or within positive regulation of stem cell proliferation IGI
IGI: 通过遗传相互作用推断
16540513 MGI
acts upstream of or within positive regulation of stem cell proliferation IMP
IMP: 通过突变表型推断
14530295 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
16989802 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
20410112 MGI
acts upstream of or within positive regulation of urothelial cell proliferation IMP
IMP: 通过突变表型推断
15843416 MGI
acts upstream of or within post-embryonic development IMP
IMP: 通过突变表型推断
16989802 MGI
acts upstream of or within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IMP
IMP: 通过突变表型推断
17215304 MGI
acts upstream of or within prostate epithelial cord elongation IMP
IMP: 通过突变表型推断
17215304 MGI
acts upstream of or within prostate gland morphogenesis IMP
IMP: 通过突变表型推断
18184727 MGI
involved in pyramidal neuron development IMP
IMP: 通过突变表型推断
20410112 MGI
acts upstream of or within regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
16989802 MGI
acts upstream of or within regulation of epithelial cell proliferation IMP
IMP: 通过突变表型推断
17215304 MGI
acts upstream of or within regulation of morphogenesis of a branching structure IMP
IMP: 通过突变表型推断
17202188 MGI
acts upstream of or within regulation of osteoblast proliferation IMP
IMP: 通过突变表型推断
12756187 MGI
acts upstream of or within regulation of smooth muscle cell differentiation IMP
IMP: 通过突变表型推断
16989802 MGI
acts upstream of or within regulation of smoothened signaling pathway IMP
IMP: 通过突变表型推断
16618415 MGI
acts upstream of or within reproductive structure development IMP
IMP: 通过突变表型推断
12666202 MGI
acts upstream of or within squamous basal epithelial stem cell differentiation involved in prostate gland acinus development IMP
IMP: 通过突变表型推断
17215304 MGI
acts upstream of or within stem cell differentiation IGI
IGI: 通过遗传相互作用推断
16442091 MGI
acts upstream of stem cell proliferation IGI
IGI: 通过遗传相互作用推断
16540513 MGI
acts upstream of stem cell proliferation IMP
IMP: 通过突变表型推断
14530295 MGI
acts upstream of or within synaptic vesicle transport IMP
IMP: 通过突变表型推断
17418794 MGI
acts upstream of or within ureteric bud development IGI
IGI: 通过遗传相互作用推断
16442091 MGI
acts upstream of urothelial cell proliferation IMP
IMP: 通过突变表型推断
15843416 MGI
acts upstream of or within ventricular cardiac muscle tissue morphogenesis IMP
IMP: 通过突变表型推断
16687131 MGI
involved in ventricular zone neuroblast division IMP
IMP: 通过突变表型推断
20410112 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in excitatory synapse IMP
IMP: 通过突变表型推断
20410112 MGI
located in nucleus IDA
IDA: 通过直接分析推断
15229180 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Fgfr2 蛋白结构

Ig

Ig: cl11960 (49 - 142)

Ig

Ig: cd00096 (76 - 80)

Ig

Ig: cd00096 (87 - 91)

Ig

Ig: cd00096 (108 - 112)

Ig

Ig: cd00096 (122 - 127)

Ig

Ig: cd00096 (135 - 138)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (172 - 175)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (172 - 266)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (183 - 188)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (192 - 200)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (206 - 211)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (214 - 216)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (225 - 228)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (232 - 237)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (246 - 253)

IgI_2_FGFR

IgI_2_FGFR: cd05857 (256 - 266)

IgI_3_FGFR2

IgI_3_FGFR2: cd05858 (274 - 378)

IgI_3_FGFR2

IgI_3_FGFR2: cd05858 (274 - 277)

IgI_3_FGFR2

IgI_3_FGFR2: cd05858 (281 - 285)

IgI_3_FGFR2

IgI_3_FGFR2: cd05858 (293 - 300)

IgI_3_FGFR2

IgI_3_FGFR2: cd05858 (304 - 311)

IgI_3_FGFR2

IgI_3_FGFR2: cd05858 (326 - 331)

IgI_3_FGFR2

IgI_3_FGFR2: cd05858 (343 - 348)

IgI_3_FGFR2

IgI_3_FGFR2: cd05858 (356 - 364)

IgI_3_FGFR2

IgI_3_FGFR2: cd05858 (367 - 375)

PTKc_FGFR2

PTKc_FGFR2: cd05101 (474 - 786)

  • 0
  • 200
  • 400
  • 600
  • 840 a.a.
蛋白主名 其他名称

fibroblast growth factor receptor 2

keratinocyte growth factor receptor

重组 Fgfr2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76339 FGFR-2 Protein, Mouse (HEK293, Fc) E9Q5C3 (R22-E263) ≥95%
HY-P76340 FGFR-2 Protein, Mouse (HEK293, His) E9Q5C3/AAA39377.1 (R22-E263) ≥95%
HY-P77661 FGFR-2 beta (IIIb) Protein, Mouse (HEK293, His) P21803-2 (P39-E263) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Fgfr2 NCBI NCBI:2263