1. 重组蛋白
  2. Cytokines and Growth Factors CD Antigens Receptor Proteins
  3. Interleukin & Receptors Neurotrophic Factors Epithelial cell CD Proteins Endothelial cell CD Proteins Cytokine Receptors
  4. IL-6R gp130/CD130
  5. Glycoprotein 130 (gp130)
  6. gp130/IL6ST 蛋白, Rat (HEK293, His-Fc)

gp130/IL6ST 蛋白, Rat (HEK293, His-Fc)

目录号: HY-P76375
产品使用指南

Glycoprotein 130 (gp130) 是一种跨膜蛋白,是白细胞介素 6 (IL-6) 家族的常见信号转导受体亚基。gp130 抑制细胞生长和迁移,降低 IL-6 诱导的 STAT3 磷酸化,降低 IL-6 诱导的 Ki67 增加。gp130 具有抗肿瘤、抗炎和抗伤害活性。gp130/IL6ST 蛋白, Rat (HEK293, His-Fc) 是一种重组蛋白,C 端带有 His 标签和 Fc 标签,由 614 个氨基酸 (M4-E618) 组成,在 HEK293 细胞中表达。

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描述

Glycoprotein 130 (gp130) is a trans-membrane protein, is the common signal-transducing receptor subunit of the interleukin-6 (IL-6) family[1]. gp130 inhibits the cell growth and migration[3], decreases the STAT3 phosphorylation induced by IL-6, and decreases IL-6-induced increase of Ki67. gp130 shows anti-tumor, anti-inflammation and anti-nociceptive activity[4][5]. gp130/IL6ST Protein, Rat (HEK293, His-Fc) is a recombinant protein with a His-Fc label that consists of 614 amino acids (M4-E618) and is produced by HEK293 cells.

研究背景

糖蛋白130 mRNA在人体内广泛表达,在隐静脉、心包、卵巢、网膜脂肪组织、腹膜、脾淋巴结和三叉神经节中表达水平最高。与胎儿器官相比,成人器官中gp130的表达显着增加。此外,与正常组织相比,gp130 在多种类型的癌症中高表达[3]
人 gp130 蛋白的氨基酸序列与小鼠和大鼠 gp130 蛋白的同源性较低。
当自分泌或旁分泌细胞因子诱导 gp130 和 α 受体亚基二聚化形成受体复合物时,gp130 信号传导启动,导致下游信号级联的激活,例如 JAK/STAT、PI3K/Akt、和 Ras/Raf/Mek/Erk1/2MAPK 通路。JAK/Stat3通路的激活诱导其靶基因表达,导致细胞生长、增殖(cyclin D、CDC25 A、c-Myc、survivin)、生存(survivin、Bcl-2、Bcl-XL)、血管生成 (VEGF) 和细胞迁移(MMP-2、MMP-7 和 MMP-9)[3]。gp130 是一种 IL-6 拮抗剂,具有抗肿瘤、抗炎和抗伤害活性[4]。gp130 降低 IL-6 诱导的 STAT3 磷酸化,并降低 IL-6 诱导的 Ki67[5] 增加。

种属

Rat

表达系统

HEK293

标签

C-mFc;C-His

蛋白编号

H9BFG4 (M4-E618)

基因 ID

25205  [NCBI]

蛋白结构
N-term
gp130 (M4-E618)
Accession # H9BFG4
mFc-His
C-term
中文名
重组大鼠 gp130/IL6ST 蛋白
同用名
Interleukin-6 receptor subunit beta; IL-6R-beta; IL-6RB; gp130; CD130
分子量

Approximately 130 kDa.

纯度

Greater than 95% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
参考文献
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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