1. Gene
  2. Il6st - interleukin 6 cytokine family signal transducer Gene

Il6st - interleukin 6 cytokine family signal transducer Gene

种属: Rattus norvegicus

同用名: Gp130; Ac1055; Il-6rb

基因 ID: 25205 | 基因类型: protein coding

关于 Il6st

功能概要

Predicted to enable several functions, including ciliary neurotrophic factor receptor activity; ciliary neurotrophic factor receptor binding activity; and scaffold protein binding activity. Predicted to contribute to cytokine receptor activity; growth factor binding activity; and interleukin-6 receptor binding activity. Involved in several processes, including interleukin-6-mediated signaling pathway; negative regulation of cytosolic calcium ion concentration; and triglyceride mobilization. Located in neuronal cell body membrane. Biomarker of brain ischemia; hepatocellular carcinoma; status epilepticus; and visual epilepsy. Human ortholog(s) of this gene implicated in arteriosclerosis; hyper IgE recurrent Infection syndrome 4; and hyperandrogenism. Orthologous to human IL6ST (interleukin 6 cytokine family signal transducer). [provided by Alliance of Genome Resources, Apr 2022]

Il6st 基因产物(1)

mRNA Protein Name
NM_001008725.3 NP_001008725.2 interleukin-6 receptor subunit beta precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in interleukin-6-mediated signaling pathway IMP
IMP: 通过突变表型推断
18280048 RGD
involved in negative regulation of cytosolic calcium ion concentration IMP
IMP: 通过突变表型推断
17437036 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: 通过突变表型推断
17322172 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
15371280 RGD
involved in triglyceride mobilization IMP
IMP: 通过突变表型推断
8843746 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in neuronal cell body membrane IDA
IDA: 通过直接分析推断
8921254 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

interleukin-6 receptor subunit beta

IL-6 receptor subunit beta

IL-6R subunit beta

interleukin 6 signal transducer

membrane glycoprotein 130

oncostatin-M receptor subunit alpha

重组 Il6st 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76374 gp130/IL6ST Protein, Rat (HEK293, His) NP_001008725.2 (Q23-E618) ≥95%
HY-P76375 gp130/IL6ST Protein, Rat (HEK293, His-Fc) H9BFG4 (M4-E618) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Il6st NCBI NCBI:3572
Mus musculus Il6st NCBI NCBI:16195
Macaca mulatta Il6st NCBI NCBI:574127