1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. TRP Channel
  3. Resolvin D2

Resolvin D2  (Synonyms: RvD2)

目录号: HY-121636 纯度: ≥99.0%
COA 产品使用指南

Resolvin D2 是 DHA 的代谢物,具有抗炎和抗感染活性。Resolvin D2 是一种高效的白细胞调节器,能控制微生物败血症。在原代感觉神经元中,Resolvin D2 是 TRPV1 (IC50 = 0.1 nM) 和 TRPA1 (IC50 = 2 nM) 的有效抑制剂。

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Resolvin D2 Chemical Structure

Resolvin D2 Chemical Structure

CAS No. : 810668-37-2

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规格 价格 是否有货 数量
25 µg (265.6 µM * 250 μL in Ethanol) ¥8000
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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons[1][2][3].

IC50 & Target

TRP Channel[3]

体内研究
(In Vivo)

Resolvin D2 induces active resolution of inflammation with pulp-like tissue regeneration after root canal infection and thus maybe suitable for treating periapical lesions[1].
Resolvin D2 decreases leukocyte:endothelial interactions in vivo by endothelial-dependent nitric oxide production, and direct modulation of leukocyte adhesion receptor expression[2].
Peripheral administration of Resolvin D2 (10 ng; Intraplantar administration) potently inhibits inflammatory pain[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult CD1 mice (male, 8–10 weeks)[3]
Dosage: 10 ng
Administration: Intraplantar administration
Result: Inhibited inflammatory pain.
分子量

376.49

Formula

C22H32O5

CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Solution, -20°C, 2 years

纯度 & 产品资料

纯度: ≥99.0%

参考文献
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Resolvin D2
目录号:
HY-121636
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