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  4. Retinestatin

Retinestatin 是一种新型多元醇聚酮化合物，可以保护 SH-SY5Y 多巴胺能细胞免受 MPP+ (HY-W008719) 诱导的细胞毒性。Retinestatin 在帕金森病体外模型中显示出神经保护作用。

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Retinestatin Chemical Structure

Retinestatin Chemical Structure

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Retinestatin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Retinestatin, a new polyol polyketide, can protect SH-SY5Y dopaminergic cells from MPP+ (HY-W008719)-induced cytotoxicity. Retinestatin shows neuroprotective effects in an in vitro model of Parkinson’s disease[1].

体外研究
(In Vitro)

Retinestatin (10 μM；预处理 24 小时) 显着减弱 MPP+ (2 mM；24 小时) 诱导的 SH-SY5Y 多巴胺能神经元细胞毒性[1]。
Retinestatin (10 μM；预处理 24 小时) 可挽救 MPP+ 诱导的 Bcl-xL 表达下调和 Bak 表达上调[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Retinestatin 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: SH-SY5Y human neuroblastoma cells
Concentration: 10 μM
Incubation Time: Pretreated for 24 h
Result: Significantly attenuated MPP+-induced cytotoxicity in SH-SY5Y dopaminergic neurons.

RT-PCR[1]

Cell Line: SH-SY5Y human neuroblastoma cells
Concentration: 10 μM
Incubation Time: Pretreated for 24 h
Result: Rescued the downregulated Bcl-xL and upregulated Bak expression induced by MPP+.
分子量

532.58

Formula

C25H40O12
结构分类
初始来源

Streptomyces
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RetinestatinOtherspolyol polyketideSH-SY5YneuroprotectiveParkinson’s diseaseInhibitorinhibitorinhibit

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Retinestatin
目录号：
HY-N12657
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