2. Apoptosis
  3. RIP kinase Necroptosis
  4. RIP1 kinase inhibitor 9

RIP1 kinase inhibitor 9 (compound SY-1) 是一种选择性的 RIP 激酶 (RIP kinase) 抑制剂。RIP1 kinase inhibitor 9 有效抑制癫痫引起的中枢炎症反应。RIP1 kinase inhibitor 9 抑制 Z-VAD-FMK (HY-16658B) 诱导的 HT-29 细胞坏死 (necroptosis)，EC50 为 7.04 nM。

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RIP1 kinase inhibitor 9 Chemical Structure

RIP1 kinase inhibitor 9 Chemical Structure

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RIP1 kinase inhibitor 9 相关抗体

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  • 生物活性

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生物活性

RIP1 kinase inhibitor 9 (compound SY-1) is a selective RIP kinase inhibitor. RIP1 kinase inhibitor 9 effectively suppresses the central inflammatory response induced by epilepsy. RIP1 kinase inhibitor 9 inhibits Z-VAD-FMK (HY-16658B)-induced necroptosis in HT-29 cells with an EC50 of 7.04 nM[1].

体外研究
(In Vitro)

RIP1 kinase inhibitor 9 (10 nM, 4 h) 有效阻止 RIP1 和 RIP3 的磷酸化，阻碍坏死体的形成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RIP1 kinase inhibitor 9 相关抗体:
体内研究
(In Vivo)

RIP1 kinase inhibitor 9 (5 mg/kg，口服；每天 1 次，连续 7 天) 抑制癫痫小鼠模型的炎症[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

411.45

Formula

C25H21N3O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RIP1 kinase inhibitor 9 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RIP1 kinase inhibitor 9RIP kinaseNecroptosisReceptor-interacting protein kinasesRIPKsystemic inflammatory response syndromeSIRSepilepsyHT-29necroptosisInhibitorinhibitorinhibit

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