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  2. LPL Receptor
  3. RP-001 hydrochloride

RP-001 hydrochloride 是一种短效皮摩尔效力的 S1P1 (EDG1) 选择性激动剂,EC50 为 9 pM。RP-001 hydrochloride 诱导 S1P1 内化和多泛素化。RP-001 hydrochloride 对 S1P2-S1P4 几乎没有活性,对 S1P5 只有中等亲和力。

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RP-001 hydrochloride Chemical Structure

RP-001 hydrochloride Chemical Structure

CAS No. : 1781880-34-9

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规格 价格 是否有货
1 mg ¥774
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Other Forms of RP-001 hydrochloride:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RP-001 hydrochloride is a picomolar short-acting S1P1 (EDG1) selective agonist, with an EC50 of 9 pM. RP-00 hydrochloride induces internalization and polyubiquitination of S1P1. RP-001 hydrochloride has little activity on S1P2-S1P4 and only moderate affinity for S1P5[1].

体外研究
(In Vitro)

RP-001 hydrochloride elicits dose-dependent lymphopenia of CD4+ T cells. RP-001 hydrochloride induces acute lymphopenia with rapid recovery to untreated levels[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

RP-001 hydrochloride causes dose-dependent rapid lymphopenia with an EC50 of 0.03 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

468.93

Formula

C24H25ClN4O4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

RP-001 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
RP-001 hydrochloride
目录号:
HY-101939A
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