2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. RS-102221

RS-102221 是一种选择性 5-HT2C 受体拮抗剂 (Ki=10 nM)。RS-102221 对 5-HT2C 受体的选择性是 5-HT2A 和 5-HT2B 受体的近 100 倍。RS-102221 能够促进新生神经细胞分化。RS-102221 增加了大鼠的食物摄入量和体重增加。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 RS-102221 hydrochloride 通常具有更好的水溶性和稳定性。

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RS-102221 Chemical Structure

RS-102221 Chemical Structure

CAS No. : 185376-97-0

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RS-102221 的其他形式现货产品:

Customer Review

Other Forms of RS-102221:

RS-102221 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RS-102221 is a selective 5-HT2C receptor antagonist (Ki=10 nM). RS-102221 shows nearly 100-fold selectivity for the 5-HT2C receptor as compared to the 5-HT2A and 5-HT2B receptors. RS-102221 can promote the differentiation of new nerve cells. RS-102221 increases food-intake and weight-gain in rats[1][2].

IC50 & Target[1]

5-HT2C Receptor

10 nM (Ki)

5-HT2A Receptor

 

5-HT2B Receptor

 

体外研究
(In Vitro)

RS102221 (0.3-300nM; 24 h) 促进小鼠成年海马神经前体细胞 (ahNPCs) 分化，并显著增加 MAP-2+ 细胞的百分比[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RS-102221 相关抗体:

Cell Differentiation Assay[1]

Cell Line: Mouse adult hippocampal neural progenitor cells (ahNPCs)
Concentration: 0.3, 1, 10, 30, 100, and 300 nM
Incubation Time: 24 hours
Result: Significantly increases the percentage of MAP-2+ cells at 10 nM.
体内研究
(In Vivo)

RS-102221 (2 mg/kg; 腹腔注射; 每天 1 次, 共 14 天) 增加大鼠的食物摄入量和体重增加[2]。
RS-102221 (2 mg/kg; 腹腔注射; 单次剂量) 与 3,4-亚甲基二氧基-N-甲基苯丙胺 (MDMA 或“摇头丸”) 联合施用于小鼠，可在前 1 小时抑制 MDMA 诱导厌食症，和 MDMA 诱导的过度运动[3]。
RS-102221 (2 mg/kg; 腹腔注射; 单次剂量) 可减轻小鼠在光暗试验中的焦虑，并降低惊吓反射的幅度[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

612.62

Formula

C27H31F3N4O7S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RS-102221 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RS-102221185376-97-0RS102221RS 1022215-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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目录号：
HY-101365
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