1. GPCR/G Protein Neuronal Signaling
  2. 5-HT Receptor
  3. RU 24969 hemisuccinate

RU 24969 hemisuccinate 是一种优先的 5-HT1B 激动剂,Ki 值为 0.38 nM,对 5-HT1A 受体也显示出明显的亲和力 (Ki=2.5 nM),对脑中其他受体部位的亲和力很低。RU 24969 hemisuccinate 可减少液体消耗并增加向前运动。

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RU 24969 hemisuccinate Chemical Structure

RU 24969 hemisuccinate Chemical Structure

CAS No. : 66611-27-6

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RU 24969 hemisuccinate is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 hemisuccinate could decrease fluid consumption and increase forward locomotion[1].

IC50 & Target[1]

5-HT1B Receptor

0.38 nM (Ki)

5-HT1A Receptor

2.5 nM (Ki)

体外研究
(In Vitro)

RU 24969 (10 μM) reduces K+-stimulated release of [3H]-5-HT from ratfrontalcortex slices in vitro[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

RU 24969 (0.03-3.0 mg/kg; s.c.) dose-dependently decreases water consumption in water deprived rats[1].
RU 24969 (0.3-3.0 mg/kg; s.c.) dose-dependently increases forward locomotion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[1]
Dosage: 0.03, 0.3, 1.0, 3.0 mg/kg
Administration: A single s.c.
Result: Decreased water consumption significantly at dose of 0.3, 1.0, and 3.0 mg/kg.
分子量

287.34

Formula

C14H16N2O.1/2C4H6O4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

RU 24969 hemisuccinate 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
RU 24969 hemisuccinate
目录号:
HY-16688B
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