2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor
  3. Glucocorticoid Receptor
  4. RU28362

RU28362 是一种有效的选择性糖皮质激素 (glucocorticoid) 激动剂。RU28362 增加神经元中 Bnip3 mRNA 水平。RU28362抑制促肾上腺皮质激素(ACTH)和皮质酮的分泌。

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RU28362 Chemical Structure

RU28362 Chemical Structure

CAS No. : 74915-64-3

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RU28362 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RU28362 is a potent and selective glucocorticoid agonist. RU28362 increases the Bnip3 mRNA levels in neurons. RU28362 inhibits adrenocorticotrophic hormone (ACTH) and corticosterone secretion[1][2]. RU28362 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

体外研究
(In Vitro)

RU28362 (0.1、1、5、10 nM; 72 小时) 会以剂量依赖性方式增加神经元中的 Bnip3 mRNA 水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RU28362 相关抗体:

RT-PCR[1]

Cell Line: Primary cortical neurons
Concentration: 0.1, 1.0, 5.0, 10.0 nM
Incubation Time: 48, 72 h
Result: Significantly increased the Bnip3 mRNA levels in a dose-dependent manner after 72 h, Bnip3 mRNA levels were not changed after treatment with RU28362 for 48 h.
体内研究
(In Vivo)

RU28362 (150 µg/kg；腹腔注射) 可抑制促肾上腺皮质激素 (ACTH) 和皮质酮的分泌，并选择性抑制应激诱导的垂体前叶 POMC hnRNA 增加[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 250-350 g, adult male Sprague-Dawley rats[2]
Dosage: 150 µg/kg
Administration: I.p.; 60 min before exposure to a 15-min period of restraint stress
Result: Inhibited adrenocorticotrophic hormone (ACTH) and corticosterone secretion and selectively suppressed the stress-induced increase in POMC hnRNA in the anterior pituitary gland.
分子量

352.47

Formula

C23H28O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RU28362 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RU2836274915-64-3RU 28362RU-28362Glucocorticoid ReceptorBnip3 mRNAneuronsACTHcorticosterone ,POMC hnRNAInhibitorinhibitorinhibit

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