2. Neuronal Signaling
  3. Imidazoline Receptor
  4. RX 801077

RX 801077  (Synonyms: 2 BFI free base)

目录号: HY-100904A
产品使用指南

摩尔计算器

RX 801077 (2 BFI free base) 是一种选择性咪唑啉 I2 受体 (imidazoline I2 receptor (I2R)) 激动剂，Ki 值为 70.1 nM。RX 801077 具有抗炎和神经保护作用。RX 801077 具有用于创伤性脑损伤 (TBI) 研究的潜力。

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RX 801077 Chemical Structure

RX 801077 Chemical Structure

CAS No. : 72583-92-7

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RX 801077 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RX 801077 (2 BFI free base) is a selective imidazoline I2 receptor (I2R) agonist with a Ki value of 70.1 nM. RX 801077 shows anti-inflammation and neuroprotection. RX 801077 has the potential for the research of traumatic brain injury (TBI)[1][2].

IC50 & Target

Ki: 70.1 nM (imidazoline I2 receptor)[2]
体内研究
(In Vivo)

RX 801077 (5、10、20 mg/kg；腹腔注射；每天两次，持续 3 天) 在创伤性脑损伤大鼠模型中抑制 NLRP3 炎性体诱导的炎症和坏死性凋亡[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 280-300 g, Male adult Sprague-Dawley rats (TBI model)[2]
Dosage: 5, 10, 20 mg/kg
Administration: I.p.; twice daily for 3 days
Result: Attenuated neurological deficits, brain edema, BBB permeability and cortical tissue loss in a rat model of TBI, reduced microglial activation, neutrophil infiltration, and proinflammatory cytokine IL-1β secretion, reduced the expression of RIP1 and RIP3 in neurons in the pericontusional cortex.
分子量

186.21

Formula

C11H10N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RX 801077 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RX 80107772583-92-72 BFIRX801077RX-801077Imidazoline Receptoranti-inflammationnecroptosisRIP1RIP3IL-1βtraumatic brain injuryInhibitorinhibitorinhibit

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