2. GPCR/G Protein
  3. Orphan GPCR
  4. SAR-446523

SAR-446523 是一种靶向 GPRC5D 的人源化 IgG1 单克隆抗体抑制剂。SAR-446523 显著诱导抗体依赖性细胞介导的细胞毒作用 (ADCC)。SAR-446523 具有强效抗肿瘤活性，可在携带多发性骨髓瘤 (MM) 细胞的 NK 人源化 NOG huIL15 转基因小鼠模型中提高小鼠生存率。SAR-446523 可用于多发性骨髓瘤 (MM) 研究。

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SAR-446523 Chemical Structure

SAR-446523 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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SAR-446523 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SAR-446523 is a humanized IgG1 monoclonal antibody inhibitor targeting GPRC5D. SAR-446523 significantly induces antibody-dependent cell-mediated cytotoxicity (ADCC). SAR-446523 has potent antitumor activity with improvement of mouse survival in NK humanized NOG huIL15 transgenic mice model bearing MM cells. SAR-446523 can be used for multiple myeloma (MM) research[1].

IC50 & Target

GPRC5D
基因 ID

55507  [NCBI]

Accession

Q9NZD1-1
靶点

GPRC5D
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SAR-446523 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SAR-446523SAR446523SAR 446523Orphan GPCRRrphan G protein-coupled receptorGPRC5DMonoclonal antibodyAntitumorNK humanized NOG huIL15 transgenic mice model bearing MM cellsMultiple myelomaMMInhibitorinhibitorinhibit

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产品名称：
SAR-446523
目录号：
HY-P991587
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