1. Screening Libraries
  2. Wnt/Hedgehog/Notch Compound Library

Wnt/Hedgehog/Notch 化合物库 - Wnt/Hedgehog/Notch Compound Library

Cat. No.: HY-L020
Library Contents: XLSX PDF SDF

发育蛋白 Hedgehog、Notch 和 Wn t是调控多种组织中细胞命运、增殖、迁移和分化的关键因子。它们相关的信号通路在肿瘤中经常被激活,特别是在罕见的癌症干细胞亚群中。

Wnt 信号通路是动物体内一条保守的通路。Wnt 信号通路失调会对胚胎发育产生严重后果,现在人们已经充分认识到 Wnt 信号通路缺陷是导致包括癌症在内的许多人类疾病的原因之一。Hedgehog 信号通路与肿瘤发生有关,在多种癌症中异常激活。Notch 信号通路在动物中高度保守。它在细胞间通讯中起重要作用,并进一步调控胚胎发育。

MCE 可以提供 142 个 Wnt/Hedgehog/Notch 信号通路相关小分子化合物,是研究干细胞及筛选抗肿瘤药物的有用工具。

Wnt/Hedgehog/Notch Compound Library
Size (Pre-dissolved DMSO or Solid) Price Stock
30 μL/well (10 mM solution) Get quote In-stock
50 μL/well (10 mM solution) Get quote In-stock
100 μL/well (10 mM solution) Get quote In-stock
250 μL/well (10 mM solution) Get quote In-stock

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Description
& Advantages

•   A unique collection of 142 small molecule inhibitors with biological activity used for Wnt/Hedgehog/Notch pathway research and screening.

•   Targets include Notch, Gli, GSK-3, Hedgehog, Porcupine, sFRP-1, Smo, Wnt, β-catenin, etc.

•   A useful tool for the research of Wnt/Hedgehog/Notch-related regulation and diseases.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA.

•   Structurally diverse, medicinally active, and cell permeable.

•   More detailed compound information with structure, IC50, and brief introduction.

•   NMR and HPLC validated to ensure high purity and quality.

•   All compounds are in stock and continuously updated.

Product Details
Formulation:
A collection of 142 Wnt/Hedgehog/Notch signaling related compounds supplied as pre-dissolved DMSO solutions or Solid
Container:
96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Storage:
-80°C
Shipping:
Blue ice
Composition

Wnt/Hedgehog/Notch Compound Library

Source: MedChem Express

Contents of Wnt/Hedgehog/Notch Compound Library
Documentation

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产品名称:
Wnt/Hedgehog/Notch Compound Library
目录号:
HY-L020
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