1. 一站式药筛
  2. 化合物库
  3. 生物活性化合物库系列
  4. 信号通路化合物库系列
  5. 神经递质受体化合物库
神经递质受体化合物库 - Neurotransmitter Receptor Compound Library

Cat. No.: HY-L062

神经递质受体(neurotransmitter receptors,NT receptors)是一类广泛存在的膜蛋白,可以与神经递质结合,进行神经信号传导。主要有两大类神经递质受体:促离子型受体和促代谢型受体。促离子型受体是一种配体门控离子通道,受体蛋白包括一个神经递质结合位点和一个离子通道。神经递质(配体)与结合位点的结合引起受体结构的构象变化,从而使离子通道打开。促代谢型受体是一类G蛋白偶联受体(GPCR),神经递质与受体结合后可以促发第二信使介导的细胞效应。

神经递质受体是很多神经系统疾病的重要靶点。许多神经活性药物通过改变神经递质受体发挥作用。更好地理解神经递质受体在疾病中的作用机制可以加快疾病的治疗。

MCE 提供 1732 种神经递质受体相关的化合物,可以用于神经系统疾病药物的筛选。

我们将在明确您的产品用途后,向符合资质的客户通过定制合成服务的方式提供 MCE 神经递质受体化合物库,我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中,1706 个产品以 10 mM 浓度提供,26 个产品以 2 mM 浓度提供。

溶液包装中,我们对于溶液状态稳定且溶解度不低于 10 mM 的产品,提供 10 mM 溶液;对于溶液状态稳定且溶解度介于 2~10 mM 的产品,我们提供 2 mM 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Compound Screening Libraries

Top Publications Citing Use of MCE Products

MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 产品资料
  • 化合物库组成

活性描述 & 特点

Biological Activity

•   A unique collection of 1732 small molecule modulators used for neurological diseases research.

•   The library contains compounds targeting neurotransmitter receptors including mAChR, nAChR, Adrenergic Receptor, Dopamine Receptor, etc.

•   A useful tool for neurological diseases drug discovery.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA.

•   Structurally diverse, medicinally active, and cell permeable.

•   Rich documentation with structure, IC50, and summary.

•   NMR and HPLC validated to ensure high purity.

•   All compounds are in stock and continuously updated.

产品详情

Product Details

Formulation:

A collection of 1732 neurotransmitter receptor compounds supplied as pre-dissolved Solutions or Solid
Solution: 1706 compounds supplied in 10 mM solution, 26 compounds supplied in 2 mM solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice

化合物库组成

Composition

iGluR (151)

mAChR (148)

mGluR (109)

nAChR (91)

ERK (4)

Akt (3)

PI3K (3)

CXCR (2)

DYRK (2)

HIV (2)

MMP (2)

NKCC (2)

PKC (2)

AMPK (1)

CaMK (1)

CaSR (1)

COMT (1)

COX (1)

EAAT (1)

EGFR (1)

FAK (1)

GlyT (1)

HBV (1)

HCV (1)

HDAC (1)

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  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称:
    Neurotransmitter Receptor Compound Library
    目录号:
    HY-L062
    需求量: