1. 一站式药筛
  2. 化合物库
  3. 生物活性化合物库系列
  4. 疾病相关化合物库
  5. 自身免疫病化合物库
自身免疫病化合物库 - Autoimmune Disease Compound Library

Cat. No.: HY-L156

自身免疫性疾病是一种病理性疾病,其特征是针对自身抗原的炎症失调。自身免疫性疾病的常规治疗抑制了一般免疫功能以调节不受控制的炎症。目前的靶向免疫疗法通过阻断炎症细胞因子、细胞表面分子和细胞内激酶来抑制主要的促炎信号通路。作为先天免疫的关键参与者,巨噬细胞和树突状细胞 (DC) 对于 Ag 呈递和促炎细胞因子的产生至关重要,如 TNF、IL-1β、IL-6、IL-23、B 细胞激活因子 (BAFF) ,以及增殖诱导配体 (APRIL,也称为 TNFSF13A)。

MCE 收录了 454 种自身免疫病相关化合物,涵盖多个靶点及亚型,如 TNF Receptor、IFNAR、JAK、Btk、TLR、IL-6、IL-17、IL-23 等,是筛选自身免疫病药物的有用工具。

我们将在明确您的产品用途后,向符合资质的客户通过定制合成服务的方式提供 MCE 自身免疫病化合物库,我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中,443 个产品以 10 mM 浓度提供,8 个产品以 2 mM 浓度提供,3 个产品以 3 mg/mL 浓度提供。

溶液包装中,我们对于溶液状态稳定且溶解度不低于 10 mM 的产品,提供 10 mM 溶液;对于溶液状态稳定且溶解度介于 2~10 mM 的产品,我们提供 2 mM 溶液;对于溶液状态稳定、分子量不确定且溶解度不低于 3 mg/mL产品,我们提供 3 mg/mL 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Compound Screening Libraries

Top Publications Citing Use of MCE Products

MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 产品资料
  • 化合物库组成

活性描述 & 特点

Biological Activity

•   A unique collection of 454 small molecules related to autoimmune diseases for high throughput screening (HTS) and high content screening (HCS).

•   Targets such as TNF Receptor, IFNAR, JAK, Btk, TLR, and more.

•   A useful tool for drug discovery.

•   Target diverse, medicinally active and cell permeable.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   High purity and quality validated by NMR and LC/MS.

产品详情

Product Details

Formulation:

A collection of 454 small molecules related to autoimmune diseases supplied as pre-dissolved Solutions or Solid
Solution: 443 compounds supplied in 10 mM solution, 8 compounds supplied in 2 mM solution, 3 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice or dry ice

化合物库组成

Composition

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  •  产品排布图
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  •  形式(固体或溶液)
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  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称:
    Autoimmune Disease Compound Library
    目录号:
    HY-L156
    需求量: