1. Screening Libraries
  2. Glycolysis Compound Library

糖酵解化合物库 - Glycolysis Compound Library

Cat. No.: HY-L058
Library Contents: XLSX PDF SDF

糖酵解是指一个葡萄糖分子分解为两个丙酮酸分子,并获得两个 ATP 的一系列代谢过程。糖酵解过程分为 10 个步骤,由一系列酶催化完成,如己糖激酶、葡萄糖-6-磷酸异构酶、磷酸果糖激酶等。体内的所有细胞都利用糖酵解来产生能量。

研究表明,大多数肿瘤细胞中都存在糖酵解增加的现象,肿瘤细胞利用糖酵解途径产生的 ATP 作为其能量供应的主要来源。这种现象被称为 Warburg 效应,被认为是肿瘤细胞恶性转化过程中最基本的代谢变化之一。由于需氧糖酵解的增加在人类癌症中特别常见,因此开发新的糖酵解抑制剂作为一类新的抗癌药物很可能具有广泛的治疗应用。

MCE 提供 324 个糖酵解相关化合物,主要靶向糖酵解过程中的一些关键酶,如 hexokinase,glucokinase,enolase,pyruvate kinase,PDHK 等,是研究糖代谢及抗肿瘤药物开发的有用工具。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
Size (Pre-dissolved Solution or Solid) Price Stock
30 μL/well (10 mM | 2 mM solution) Get quote In-stock
50 μL/well (10 mM | 2 mM solution) Get quote In-stock
100 μL/well (10 mM | 2 mM solution) Get quote In-stock
2 × 100 μL/well (10 mM | 2 mM solution) Get quote In-stock

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Description
& Advantages

•   A unique collection of 324 glycolysis-related small molecules for high throughput screening (HTS) and high content screening (HCS).

•   Targets such as hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc.

•   A useful tool for glucose metabolism research and anti-cancer drug discovery.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA.

•   Structurally diverse, medicinally active, and cell permeable.

•   More detailed compound information with structure, IC50, and brief introduction.

•   NMR and HPLC validated to ensure high purity and quality.

•   All compounds are in stock and continuously updated.

Product Details
Formulation:
A collection of 324 glycolysis compounds supplied as pre-dissolved DMSO solutions or Solid .
Solution: 318 compounds supplied in 10 mM solution, 6 compounds supplied in 2 mM solution.
Container:
96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Storage:
-80°C
Shipping:
Blue ice
Composition

Glycolysis Compound Library

Source: MedChem Express

Contents of Glycolysis Compound Library
Documentation

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    产品名称:
    Glycolysis Compound Library
    目录号:
    HY-L058
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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack