1. 一站式药筛
  2. 化合物库
  3. 生物活性化合物库系列
  4. 信号通路化合物库系列
  5. 转录因子化合物库
转录因子化合物库 - Transcription Factor-Targeted Library

Cat. No.: HY-L090

转录是 DNA 中遗传信息转化为蛋白质的第一步,也是调控基因表达的重要环节。蛋白编码基因的转录是由 RNA 聚合酶 II 和被称为转录因子 (TFs) 的一系列辅助蛋白完成。转录因子在细胞生长、分化和对环境信号的响应的长期调控中发挥重要的作用。转录因子调节失调与多种疾病发生有关,如糖尿病,炎症相关疾病及癌症等。因此这些转录因子作为药物靶点具有较高疾病治疗价值。

MCE 收录了 1278 种靶向转录因子的小分子化合物,MCE 转录因子化合物库是研究转录因子作为治疗靶点及转录因子在疾病调控中的作用机制的有用工具。

我们将在明确您的产品用途后,向符合资质的客户通过定制合成服务的方式提供 MCE 转录因子化合物库,我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中,1260 个产品以 10 mM 浓度提供,18 个产品以 2 mM 浓度提供。

溶液包装中,我们对于溶液状态稳定且溶解度不低于 10 mM 的产品,提供 10 mM 溶液;对于溶液状态稳定且溶解度介于 2~10 mM 的产品,我们提供 2 mM 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Compound Screening Libraries

Top Publications Citing Use of MCE Products

MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 产品资料
  • 化合物库组成

活性描述 & 特点

Biological Activity

•   A unique collection of 1278 small molecule compounds with validated transcription factor targets modulating properties.

•   Targeting more than 60 transcription factors, such as AP-1, ATF6, BCL6, NF-κB, etc.

•   A useful tool for the research of transcription factor-related regulation and diseases.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

•   Structurally diverse, medicinally active, and cell permeable.

•   Detailed compound information with structure, IC50, and brief introduction.

•   Validated NMR and HPLC to ensure high purity and quality.

•   All compounds are in stock and continuously updated.

产品详情

Product Details

Formulation:

A collection of 1278 epigenetics related compounds supplied as pre-dissolved Solutions or Solid.
Solution: 1260 compounds supplied in 10 mM solution, 18 compounds supplied in 2 mM solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode.

Storage:

-80°C

Shipping:

Blue ice

化合物库组成

Composition

NF-κB (257)

PPAR (115)

STAT (107)

JNK (44)

ERK (32)

Wnt (32)

COX (30)

Akt (28)

ROR (27)

Notch (26)

YAP (26)

c-Myc (21)

JAK (17)

CDK (14)

HIV (11)

HSP (11)

AMPK (10)

MMP (9)

IKK (8)

PARP (8)

PI3K (8)

AP-1 (5)

EGFR (5)

KLF (5)

mTOR (5)

Gli (4)

GLUT (4)

相关服务推荐
定制您专属的化合物库
  •  特定化合物
  •  化合物数量
  •  产品排布图
  •  浓度
  •  形式(固体或溶液)
  •  YES
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  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称:
    Transcription Factor-Targeted Library
    目录号:
    HY-L090
    需求量: