2. Metabolic Enzyme/Protease
  3. MetAP
  4. SDX-7539

SDX-7539 是一种具有选择性的 MetAP2 抑制剂。SDX-7539 可以抑制 HUVEC 增殖，IC50 为 120 μM。SDX-7539 在 异种移植 NSCLC 的无胸腺裸鼠中表现出抗肿瘤活性。

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SDX-7539 Chemical Structure

SDX-7539 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

SDX-7539 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SDX-7539 is a selective inhibitor for Methionine aminopeptidase type 2 (MetAP2). SDX-7539 inhibits proliferarion of HUVECs with an IC50 of 120 μM. SDX-7539 exhibits antitumor activity in NSCLC xenograft athymic nude mice[1].

体内研究
(In Vivo)

SDX-7539 (37 mg/kg，静脉注射，每两天一次共 20 天) 在 A549 异种移植的无胸腺裸鼠体内表现出肿瘤抑制活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A549 xenograft athymic nude mice[1]
Dosage: 37 mg/kg
Administration: i.v., every two days for 20 days
Result: Inhibited tumor growth.
分子量

422.56

Formula

C23H38N2O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SDX-7539 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SDX-7539SDX7539SDX 7539MetAPMethionine AminopeptidaseHUVECA549NSCLCnon-small cell lung cancerInhibitorinhibitorinhibit

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