2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. HMG-CoA Reductase (HMGCR) Reactive Oxygen Species (ROS)
  4. Simvastatin hydroxy acid sodium

Simvastatin hydroxy acid sodium  (Synonyms: 辛伐他汀钠盐; Tenivastatin sodium; Simvastatin Impurity A sodium)

目录号: HY-115292 纯度: 99.86%
COA 产品使用指南 技术支持

Simvastatin hydroxy acid (Tenivastatin) sodium 是一种有效的 HMG-CoA 还原酶 (HMGCR) 抑制剂。Simvastatin hydroxy acid sodium 降低吲哚酚硫酸盐 (Indoxyl sulfate) 介导的活性氧 (ROS) 产生。Simvastatin hydroxy acid sodium 也可调节心肌细胞和转染 OATP3A1 基因的 HEK293 细胞的 OATP3A1 表达。

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Simvastatin hydroxy acid sodium

Simvastatin hydroxy acid sodium Chemical Structure

CAS No. : 101314-97-0

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥7970
In-stock
1 mg ￥1580
In-stock
5 mg ￥3160
In-stock
10 mg ￥4100
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

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Other Forms of Simvastatin hydroxy acid sodium:

Simvastatin hydroxy acid sodium 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Simvastatin hydroxy acid (Tenivastatin) sodium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin hydroxy acid sodium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin hydroxy acid sodium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1][2].

IC50 & Target

HMG-CoA reductase, Reactive oxygen species[1][2]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 IC50
12 nM
Compound: simvastatin (salt)
Concentration required to inhibit HMG-CoA reductase by 50% was determined in Hep G2 cell line
Concentration required to inhibit HMG-CoA reductase by 50% was determined in Hep G2 cell line
[PMID: 1527791]
HES IC50
6.5 nM
Compound: simvastatin (salt)
Concentration required to inhibit HMG-CoA reductase by 50% was determined in HES 9 cell line
Concentration required to inhibit HMG-CoA reductase by 50% was determined in HES 9 cell line
[PMID: 1527791]
体外研究
(In Vitro)

Simvastatin acid (0.1-20 μM; 24 h) significantly decreases ROS production between 8.9% and 43% in Indoxyl sulfate-treated hCM cells[2].
Simvastatin acid (0.1-20 μM; 24 h) alters the protein expression of OATP3A1 in hCMs and OATP3A1-expressing HEK293 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Simvastatin hydroxy acid sodium 相关抗体:

Western Blot Analysis[2]

Cell Line: hCM and HEK293 (transfected with OATP3A1)
Concentration: 0.1, 1, 10 and 20 μM
Incubation Time: 24 h
Result: Decreased 1.5% to 90% in OATP3A1 expression with a dose-dependent manner in both hCMs and OATP3A1-expressing cells.
分子量

458.56

Formula

C25H39NaO6
CAS 号
性状

固体

颜色

White to light brown

中文名称

辛伐他汀EP杂质A Sodium Salt
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (218.07 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1807 mL 10.9037 mL 21.8074 mL
5 mM 0.4361 mL 2.1807 mL 4.3615 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.86%

COA (289 KB) HNMR (273 KB) LCMS (97 KB)

产品使用指南 (1538 KB)
参考文献

Simvastatin hydroxy acid sodium 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1807 mL 10.9037 mL 21.8074 mL 54.5185 mL
5 mM 0.4361 mL 2.1807 mL 4.3615 mL 10.9037 mL
10 mM 0.2181 mL 1.0904 mL 2.1807 mL 5.4518 mL
15 mM 0.1454 mL 0.7269 mL 1.4538 mL 3.6346 mL
20 mM 0.1090 mL 0.5452 mL 1.0904 mL 2.7259 mL
25 mM 0.0872 mL 0.4361 mL 0.8723 mL 2.1807 mL
30 mM 0.0727 mL 0.3635 mL 0.7269 mL 1.8173 mL
40 mM 0.0545 mL 0.2726 mL 0.5452 mL 1.3630 mL
50 mM 0.0436 mL 0.2181 mL 0.4361 mL 1.0904 mL
60 mM 0.0363 mL 0.1817 mL 0.3635 mL 0.9086 mL
80 mM 0.0273 mL 0.1363 mL 0.2726 mL 0.6815 mL
100 mM 0.0218 mL 0.1090 mL 0.2181 mL 0.5452 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Simvastatin hydroxy acid101314-97-0TenivastatinSimvastatin Impurity A辛伐他汀EP杂质A Sodium SaltHMG-CoA Reductase (HMGCR)Reactive Oxygen Species (ROS)cardiomyocytesHEK293hCMOATP3A1Inhibitorinhibitorinhibit

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