2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. HMG-CoA Reductase (HMGCR) Reactive Oxygen Species
  4. Simvastatin hydroxy acid sodium

Simvastatin hydroxy acid sodium  (Synonyms: 辛伐他汀钠盐; Tenivastatin sodium; Simvastatin Impurity A sodium)

目录号: HY-115292
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摩尔计算器

Simvastatin hydroxy acid (Tenivastatin) sodium 是一种有效的 HMG-CoA 还原酶 (HMGCR) 抑制剂。Simvastatin hydroxy acid sodium 降低吲哚酚硫酸盐 (Indoxyl sulfate) 介导的活性氧 (ROS) 产生。Simvastatin hydroxy acid sodium 也可调节心肌细胞和转染 OATP3A1 基因的 HEK293 细胞的 OATP3A1 表达。

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Simvastatin hydroxy acid sodium Chemical Structure

Simvastatin hydroxy acid sodium Chemical Structure

CAS No. : 101314-97-0

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规格 价格 是否有货 数量
1 mg ￥1580
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Other Forms of Simvastatin hydroxy acid sodium:

Simvastatin hydroxy acid sodium 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Simvastatin hydroxy acid (Tenivastatin) sodium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin hydroxy acid sodium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin hydroxy acid sodium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1][2].

IC50 & Target

HMG-CoA reductase, Reactive oxygen species[1][2]
体外研究
(In Vitro)

Simvastatin acid (0.1-20 μM; 24 h) significantly decreases ROS production between 8.9% and 43% in Indoxyl sulfate-treated hCM cells[2].
Simvastatin acid (0.1-20 μM; 24 h) alters the protein expression of OATP3A1 in hCMs and OATP3A1-expressing HEK293 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Simvastatin hydroxy acid sodium 相关抗体:

Western Blot Analysis[2]

Cell Line: hCM and HEK293 (transfected with OATP3A1)
Concentration: 0.1, 1, 10 and 20 μM
Incubation Time: 24 h
Result: Decreased 1.5% to 90% in OATP3A1 expression with a dose-dependent manner in both hCMs and OATP3A1-expressing cells.
分子量

458.56

Formula

C25H39NaO6
CAS 号
中文名称

辛伐他汀EP杂质A Sodium Salt
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Simvastatin hydroxy acid sodium 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Simvastatin hydroxy acid101314-97-0TenivastatinSimvastatin Impurity A辛伐他汀EP杂质A Sodium SaltHMG-CoA Reductase (HMGCR)Reactive Oxygen SpeciescardiomyocytesHEK293hCMOATP3A1Inhibitorinhibitorinhibit

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