1. Metabolic Enzyme/Protease
  2. HMG-CoA Reductase (HMGCR)
  3. Simvastatin hydroxy acid sodium

Simvastatin hydroxy acid sodium (Synonyms: Tenivastatin sodium; Simvastatin Impurity A sodium)

目录号: HY-115292
产品使用指南

Simvastatin hydroxy acid sodium (Tenivastatin sodium; Simvastatin Impurity A sodium) 是辛伐他汀 (HY-17502) 活性水解代谢物。Simvastatin 是一种竞争性的 HMG-CoA 还原酶抑制剂, Ki 值为 0.2 nM。

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Simvastatin hydroxy acid sodium Chemical Structure

Simvastatin hydroxy acid sodium Chemical Structure

CAS No. : 101314-97-0

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Description

Simvastatin hydroxy acid sodium (Tenivastatin sodium; Simvastatin Impurity A sodium) is an active hydrolytic metabolite of Simvastatin (HY-17502)[1]. Simvastatin shows a inhibition of HMG-CoA reductase with a Ki value of 0.12 nM[2].

In Vitro

Simvastatin sodium shows a inhibition of HMG-CoA reductase in human lymphoblasts and SV40 transformed MRCS fibroblasts[1].
Simvastatin sodium (100 μM) inhibits the Na+/H+ antiport activity leading to a fall of intracellular pH and to a reduced cell proliferation.And the inhibitory effect is prevented by mevalonate but not dolichol or squalene[1].

In Vivo

Simvastatin sodium (oral administration; 8 mg/kg; 18 days) reduces plasma cholesterol levels 33%, simvastatin can be used in combination with ezetimibe to treat dyslipidemia[1].

Molecular Weight

458.56

Formula

C₂₅H₃₉NaO₆

CAS No.

101314-97-0

SMILES

CCC(C)(C)C(O[C@@H]1[C@@]2([H])C(C=C[C@H](C)[C@@H]2CC[C@@H](O)C[C@@H](O)CC(O[Na])=O)=C[C@H](C)C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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Keywords:

Simvastatin hydroxy acidTenivastatinSimvastatin Impurity AHMG-CoA Reductase (HMGCR)prodrugHMG-CoAInhibitorinhibitorinhibit

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产品名称:
Simvastatin hydroxy acid sodium
目录号:
HY-115292
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