2. Cell Cycle/DNA Damage
  3. LIM Kinase (LIMK)
  4. SM311

SM311 (Compound 10) 是一种强效的选择性不可逆的 LIMK1 抑制剂 (EC50=0.045 μM，对 LIMK2 的选择性超过 30 倍)。SM311 能够阻断丝切蛋白磷酸化和肌动蛋白细胞骨架的调节。SM311 有望用于诸如脆性 X 综合征 (FXS) 和阿尔茨海默病等神经退行性疾病以及肿瘤侵袭的研究。

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SM311 Chemical Structure

SM311 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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Customer Review

SM311 相关抗体

Top Publications Citing Use of Products

查看 LIM Kinase (LIMK) 亚型特异性产品:

查看所有亚型
LIMK1 LIMK2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SM311 (Compound 10) is a potent selective irreversible LIMK1 inhibitor (EC50=0.045 μM, >30-fold selective over LIMK2). SM311 blocks cofilin phosphorylation and actin cytoskeleton regulation. SM311 is promising for research of neurodegenerative diseases like Fragile X syndrome (FXS) and Alzheimer’s disease, as well as tumor invasion[1].

IC50 & Target

LIMK1

0.045 μM (EC50)

LIMK2

 

分子量

431.46

Formula

C20H19F2N5O2S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SM311 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SM311SM 311SM-311LIM Kinase (LIMK)LIMKsLIMK1LIMK2neurodegenerative diseasestumor invasionInhibitorinhibitorinhibit

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目录号：
HY-174229
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