1. Cell Cycle/DNA Damage
    Cytoskeleton
    Apoptosis
  2. Microtubule/Tubulin
    Apoptosis
  3. SS28

SS28 

目录号: HY-100761
产品使用指南

SS28是具有口服生物利用度的SRT501 类似物,可抑制微管蛋白聚合,在G2/M引起细胞周期阻滞。SS28会引起细胞凋亡而不是坏死。

MCE 的所有产品仅用作科学研究,我们不为任何个人用途提供产品和服务

SS28 Chemical Structure

SS28 Chemical Structure

CAS No. : 141172-08-9

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

Size Stock
100 mg Get quote
250 mg Get quote
500 mg Get quote

* Please select Quantity before adding items.

Customer Review

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

Description

SS28, a SRT501 analog with oral bioavailability, inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase. SS28 results in apoptosis rather than necrosis tubulin[1].

IC50 & Target

Tubulin[1].

In Vitro

SS28 (0-20 μM) induces cytotoxicity in different cancer cell lines[1].
SS28 treatment (5 μM for A549 and 2 μM for CEM) results in cell cycle arrest at G2/M phase leading to apoptosis upon further incubation[1].

Cell Proliferation Assay[1]

Cell Line: CEM, Reh, Nalm6, SUDHL8, Molt4, A549, HeLa 293T cells.
Concentration: 1, 5, 10 and 20 μM.
Incubation Time: 48 and 72 h.
Result: CEM and A549 exhibited maximum sensitivity to SS28 followed by SUDHL8, Molt4 and Reh, whereas Nalm6 showed moderate sensitivity after 48 h of the treatment. IC50 values of SS28 in CEM and A549 cell line were 2.6 and 5.2 μM, respectively, whereas in SUDHL8, Molt4, Reh and Nalm6 were 2.7, 5.1, 7.9 and 21 μ M, respectively after 48 h of treatment.

Cell Cycle Analysis[1]

Cell Line: CEM and A549 cells.
Concentration: 2 μM (CEM) and 5 μM (A549).
Incubation Time: 6, 12, 18, 24 and 30 h.
Result: Showed significant accumulation of cells at G2/M phase in a time-dependent manner (6 to 24 h) and a subsequent increase in the sub-G1 population, indicative of apoptosis at 30 h in case of A549. Similarly, studies in CEM also showed a distinct G2/M arrest after 12 h of treatment, as compared to vehicle control.
In Vivo

SS28 (15 mg/kg. b.wt.) treatment results in inhibition of tumor cell proliferation[1].

Animal Model: BALB/c mice using EAC cells[1].
Dosage: 15 mg/kg.
Administration: Orally on every alternate day for 9 doses.
Result: There was no further tumor progression in the mice when SS28 was administered, unlike the untreated tumor control mice.
Molecular Weight

284.35

Formula

C₁₈H₂₀O₃

CAS No.

141172-08-9

SMILES

CC1=CC=C(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
SS28
目录号:
HY-100761
需求量: