2. Anti-infection
  3. Fungal
  4. T-2307

T-2307 是一种芳基脒，在体外和体内具有抗真菌活性。T-2307 具有广谱抗菌活性，包括念珠菌属 (Candida， MIC 为 0.00025 至 0.0078 μg/mL)、新型隐球菌属 (Cryptococcus neoformans，MIC 为 0.0039-0.0625 μg/mL) 和曲霉属 (Aspergillus；MIC 为 0.0156-4 μg/mL)。

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T-2307 Chemical Structure

T-2307 Chemical Structure

CAS No. : 873546-31-7

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥4400
In-stock
1 mg ￥1818
In-stock
5 mg ￥4000
In-stock
10 mg ￥6800
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

T-2307 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

T-2307, an arylamidine, has antifungal activities in vitro and in vivo. T-2307 exhibits broad-spectrum activity against clinically significant pathogens, including Candida species (MIC range, 0.00025 to 0.0078 μg/ml), Cryptococcus neoformans (MIC range, 0.0039 to 0.0625 μg/ml), and Aspergillus species (MIC range, 0.0156 to 4 μg/mL) [1].

体外研究
(In Vitro)

T-2307 exhibits potent activity against fluconazole-resistant and fluconazole-susceptible-dose-dependent Candida albicans strains as well as against azole-susceptible strains[1].
T-2307 shows efficacy in a murine model of candida glabrata infection despite in vitro trailing growth phenomena[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

T-2307 相关抗体:

Cell Viability Assay[2]

Cell Line: C. glabrata ATCC 90030
Concentration: 0.000125, 0.00025, 0.0005, 0.001, 0.002, 0.0039, 0.0078, 0.0156, 0.0313, 0.0625, 0.125 μg/mL
Incubation Time: 24 and 48 hours
Result: C. glabrata exhibited significant trailing growth at concentrations between 0.0039 and 0.125 μg/mL at 48 h.
The trailing growth of C. glabrata at 24 h of incubation was similar to that at 48 h.
体内研究
(In Vivo)

In mouse models of disseminated candidiasis, cryptococcosis, and aspergillosis, the ED50 of T-2307 were 0.00755, 0.117, and 0.391 mg/kg, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-week-old specific-pathogen-free ICR strain male mice bearing systemic infections with Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus[1].
Dosage: 0.001, 0.1, 1 mg/kg
Administration: Subcutaneously administered; once a day for 7 days, beginning at 2 h after the infection.
Result: In the systemic infection caused by Candida albicans, all the control mice died by day 6. Mortality was significantly delayed in mice that were administered T-2307 at a dose of 0.01 mg/kg compared with that in the control mice. The calculated ED50s of T-2307were 0.00755 mg/kg.
In the systemic infection caused by Cryptococcus neoformans, all the control mice died by day 9. Mortality was significantly delayed in mice administered T-2307 at a dose of 0.1 mg/kg compared with that in the control mice. The calculated ED50s of T-2307 were 0.117 mg/kg.
In the systemic infection caused by Aspergillus fumigatus, all the control mice died by day 6. Mortality was significantly delayed in mice that were administered T-2307 at a dose of 1 mg/kg compared with that in the control mice. The calculated ED50s of T-2307 were 0.391 mg/kg.
分子量

437.58

Formula

C25H35N5O2
CAS 号
性状

固体

颜色

Off-white to light brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 50 mg/mL (114.26 mM; 超声助溶; 酸性条件溶解 (HCL 调节，pH≈3); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2853 mL 11.4265 mL 22.8530 mL
5 mM 0.4571 mL 2.2853 mL 4.5706 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

T-2307 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2853 mL 11.4265 mL 22.8530 mL 57.1324 mL
5 mM 0.4571 mL 2.2853 mL 4.5706 mL 11.4265 mL
10 mM 0.2285 mL 1.1426 mL 2.2853 mL 5.7132 mL
15 mM 0.1524 mL 0.7618 mL 1.5235 mL 3.8088 mL
20 mM 0.1143 mL 0.5713 mL 1.1426 mL 2.8566 mL
25 mM 0.0914 mL 0.4571 mL 0.9141 mL 2.2853 mL
30 mM 0.0762 mL 0.3809 mL 0.7618 mL 1.9044 mL
40 mM 0.0571 mL 0.2857 mL 0.5713 mL 1.4283 mL
50 mM 0.0457 mL 0.2285 mL 0.4571 mL 1.1426 mL
60 mM 0.0381 mL 0.1904 mL 0.3809 mL 0.9522 mL
80 mM 0.0286 mL 0.1428 mL 0.2857 mL 0.7142 mL
100 mM 0.0229 mL 0.1143 mL 0.2285 mL 0.5713 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

T-2307873546-31-7T2307T 2307FungalarylamidineantifungalbroadspectrumCandidaCryptococcusneoformansAspergillusInhibitorinhibitorinhibit

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